ArticleEuropean journal of human genetics : EJHG2014
Genome-wide estimates of inbreeding in unrelated individuals and their association with cognitive ability.
Article in European journal of human genetics : EJHG, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Declining autozygosity over time: An exploration in over 1 million individuals from three diverse cohorts.American journal of human genetics · 2023Pooled it
- Exploring the Relationships Between Autozygosity, Educational Attainment, and Cognitive Ability in a Contemporary, Trans-Ancestral American Sample.Behavior genetics · 2022Article
- Genome-Wide Homozygosity Mapping Reveals Genes Associated With Cognitive Ability in Children From Saudi Arabia.Frontiers in genetics · 2019Article
- Genomic analysis of family data reveals additional genetic effects on intelligence and personality.Molecular psychiatry · 2018Article
- Effects of autozygosity and schizophrenia polygenic risk on cognitive and brain developmental trajectories.European journal of human genetics : EJHG · 2018Article
- Relationship between Deleterious Variation, Genomic Autozygosity, and Disease Risk: Insights from The 1000 Genomes Project.American journal of human genetics · 2018Article
- Runs of homozygosity: windows into population history and trait architecture.Nature reviews. Genetics · 2018Review
- Weighted likelihood inference of genomic autozygosity patterns in dense genotype data.BMC genomics · 2017Article
- GARLIC: Genomic Autozygosity Regions Likelihood-based Inference and Classification.Bioinformatics (Oxford, England) · 2017Article
- Genome-wide autozygosity is associated with lower general cognitive ability.Molecular psychiatry · 2016Article
- Article
- Educational attainment influences levels of homozygosity through migration and assortative mating.PloS one · 2015Article
- The association of genotype-based inbreeding coefficient with a range of physical and psychological human traits.PloS one · 2014Article
- Estimating the inbreeding depression on cognitive behavior: a population based study of child cohort.PloS one · 2014Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The consequence of reduced cognitive ability from inbreeding has long been investigated, mainly restricted to cousin-cousin marriages. Molecular genetic techniques now allow us to test the relationship between increased ancestral inbreeding and cognitive ability in a population of traditionally unrelated individuals. In a representative UK sample of 2329 individuals, we used genome-wide SNP data to estimate the percentage of the genome covered by runs of homozygous SNPs (ROH). This was tested for association with general cognitive ability, as well as measures of verbal and non-verbal ability. Further, association was tested between these traits and specific ROH. Burden of ROH was not associated with cognitive ability after correction for multiple testing, although burden of ROH was nominally associated with increased non-verbal cognitive ability (P=0.03). Moreover, although no individual ROH was significantly associated with cognitive ability, there was a significant bias towards increased cognitive ability in carriers of ROH (P=0.002). A potential explanation for these results is increased positive assortative mating in spouses with higher cognitive ability, although we found no evidence in support of this hypothesis in a separate sample. Reduced minor allele frequency across the genome was associated with higher cognitive ability, which could contribute to an apparent increase in ROH. This may reflect minor alleles being more likely to be deleterious.
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