Evidence map›Paper›PMID 23860039›Full record

ArticleEuropean journal of human genetics : EJHG2014

Testing personalized medicine: patient and physician expectations of next-generation genomic sequencing in late-stage cancer care.

Fiona A Miller, Robin Z Hayeems, Jessica P Bytautas, Philippe L Bedard, Scott Ernst, Hal Hirte, Sebastien Hotte, Amit Oza, Albiruni Razak, Stephen Welch and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of human genetics : EJHG, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 120 citations in OpenAlex.

  1. Pooled it
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  10. Preparing for the unexpected: Recommendations for returning secondary findings in late-stage cancer care.Genetics in medicine : official journal of the American College of Medical Genetics · 2024
    Article
  11. Article
  12. The Impact of an Educational Video in Arabic Language on Patients' Knowledge and Attitudes Towards Genetic Testing for Cancer Therapy.Journal of cancer education : the official journal of the American Association for Cancer Education · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Fiona A Miller1] Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada [2] Joint Centre for Bioethics, University of Toronto, Toronto, ON, Canada.
Robin Z HayeemsInstitute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.
Jessica P BytautasInstitute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.
Philippe L BedardPrincess Margaret Cancer Centre-University Health Network, Toronto, ON, Canada.
Scott ErnstLondon Health Sciences Centre, London, ON, Canada.
Hal HirteJuravinski Cancer Centre, Hamilton, ON, Canada.
Sebastien HotteJuravinski Cancer Centre, Hamilton, ON, Canada.
Amit OzaPrincess Margaret Cancer Centre-University Health Network, Toronto, ON, Canada.
Albiruni RazakPrincess Margaret Cancer Centre-University Health Network, Toronto, ON, Canada.
Stephen WelchLondon Health Sciences Centre, London, ON, Canada.
Eric WinquistLondon Health Sciences Centre, London, ON, Canada.
Janet DanceyOntario Institute for Cancer Research, Toronto, ON, Canada.
Lillian L SiuPrincess Margaret Cancer Centre-University Health Network, Toronto, ON, Canada.
London Health Sciences Centre · CAPrincess Margaret Cancer Centre · CAJuravinski Cancer Centre · CAUniversity of Toronto · CAOntario Institute for Cancer Research · CAUniversity Health Network · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Developments in genomics, including next-generation sequencing technologies, are expected to enable a more personalized approach to clinical care, with improved risk stratification and treatment selection. In oncology, personalized medicine is particularly advanced and increasingly used to identify oncogenic variants in tumor tissue that predict responsiveness to specific drugs. Yet, the translational research needed to validate these technologies will be conducted in patients with late-stage cancer and is expected to produce results of variable clinical significance and incidentally identify genetic risks. To explore the experiential context in which much of personalized cancer care will be developed and evaluated, we conducted a qualitative interview study alongside a pilot feasibility study of targeted DNA sequencing of metastatic tumor biopsies in adult patients with advanced solid malignancies. We recruited 29/73 patients and 14/17 physicians; transcripts from semi-structured interviews were analyzed for thematic patterns using an interpretive descriptive approach. Patient hopes of benefit from research participation were enhanced by the promise of novel and targeted treatment but challenged by non-findings or by limited access to relevant trials. Family obligations informed a willingness to receive genetic information, which was perceived as burdensome given disease stage or as inconsequential given faced challenges. Physicians were optimistic about long-term potential but conservative about immediate benefits and mindful of elevated patient expectations; consent and counseling processes were expected to mitigate challenges from incidental findings. These findings suggest the need for information and decision tools to support physicians in communicating realistic prospects of benefit, and for cautious approaches to the generation of incidental genetic information.

Indexed as

Genome, HumanAdultAgedAged, 80 and overDecision MakingDNA, NeoplasmFemaleGenetic Predisposition to DiseaseHigh-Throughput Nucleotide SequencingHumansMaleMiddle AgedNeoplasmsNeoplasm StagingPatient Education as TopicPatientsDNA, Neoplasm

Identifiers

PMID23860039
PMCPMC3925281
OpenAlexW2025342001

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.