ArticleJournal of the American Chemical Society2013
Electron flow through nitrotyrosinate in Pseudomonas aeruginosa azurin.
Article in Journal of the American Chemical Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- The pH-dependence of copper(ii/i) reduction potentials in variants ofRSC advances · 2026Article
- Electron Transport through a Tryptophan Quadruplex in a Dimeric Azurin Construct.The journal of physical chemistry. B · 2026Article
- The Influence of pH on Long-Range Electron Transfer and Proton-Coupled Electron Transfer in Ruthenium-Modified Azurin.Molecules (Basel, Switzerland) · 2025Article
- An Investigation of the Influence of Tyrosine Local Interactions on Electron Hopping in a Model Protein.Molecules (Basel, Switzerland) · 2024Article
- A versatile artificial metalloenzyme scaffold enabling direct bioelectrocatalysis in solution.Science advances · 2022Article
- Mimicking Natural Photosynthesis: Designing Ultrafast Photosensitized Electron Transfer into Multiheme Cytochrome Protein Nanowires.Nanomaterials (Basel, Switzerland) · 2020Article
- Competing ultrafast photoinduced electron transfer and intersystem crossing of [Re(CO)Theoretical chemistry accounts · 2020Article
- Hole Hopping Across a Protein-Protein Interface.The journal of physical chemistry. B · 2019Article
- Two Tryptophans Are Better Than One in Accelerating Electron Flow through a Protein.ACS central science · 2019Article
- Fluctuating hydrogen-bond networks govern anomalous electron transfer kinetics in a blue copper protein.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Driving Protein Conformational Changes with Light: Photoinduced Structural Rearrangement in a Heterobimetallic Oxidase.Journal of the American Chemical Society · 2018Article
- Mechanically Controlled Electron Transfer in a Single-Polypeptide Transistor.Scientific reports · 2017Article
- Insights into an efficient light-driven hybrid P450 BM3 enzyme from crystallographic, spectroscopic and biochemical studies.Biochimica et biophysica acta · 2016Article
- Redox Signaling through DNA.Israel journal of chemistry · 2016Article
- Constraints on the Radical Cation Center of Cytochrome c Peroxidase for Electron Transfer from Cytochrome c.Biochemistry · 2016Article
- Stopped-Flow Studies of the Reduction of the Copper Centers Suggest a Bifurcated Electron Transfer Pathway in Peptidylglycine Monooxygenase.Biochemistry · 2016Article
- Proton-coupled electron hopping in Ru-modified P. aeruginosa azurin.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2016Article
- Electron flow through biological molecules: does hole hopping protect proteins from oxidative damage?Quarterly reviews of biophysics · 2015Review
- Could tyrosine and tryptophan serve multiple roles in biological redox processes?Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2015Article
- Mechanisms for control of biological electron transfer reactions.Bioorganic chemistry · 2014Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
We have designed ruthenium-modified Pseudomonas aeruginosa azurins that incorporate 3-nitrotyrosine (NO2YOH) between Ru(2,2'-bipyridine)2(imidazole)(histidine) and Cu redox centers in electron transfer (ET) pathways. We investigated the structures and reactivities of three different systems: RuH107NO2YOH109, RuH124NO2YOH122, and RuH126NO2YOH122. RuH107NO2YOH109, unlabeled H124NO2YOH122, and unlabeled H126NO2YOH122 were structurally characterized. The pKa's of NO2YOH at positions 122 and 109 are 7.2 and 6.0, respectively. Reduction potentials of 3-nitrotyrosinate (NO2YO(-))-modified azurins were estimated from cyclic and differential pulse voltammetry data: oxidation of NO2YO(-)122 occurs near 1.1 versus NHE; oxidation of NO2YO(-)109 is near 1.2 V. Our analysis of transient optical spectroscopic experiments indicates that hopping via NO2YO(-) enhances Cu(I) oxidation rates over single-step ET by factors of 32 (RuH107NO2YO(-)109), 46 (RuH126NO2YO(-)122), and 13 (RuH124NO2YO(-)122).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.