Evidence map›Paper›PMID 23858327›Full record

ArticleTherapeutic advances in neurological disorders2013

Sex and gender issues in multiple sclerosis.

Hanne F Harbo, Ralf Gold, Mar Tintoré

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic advances in neurological disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07011875 (The Effect of Physical Activity Levels on Dysmenorrhea Severity, Menstrual Symptoms, and Functional and Emotional Status in Women Diagnosed With Multiple Sclerosis), which is not on this map. Cited by 256 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
256citing papers in PubMed, 9 pooled it
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07011875 enrolling by invitationnot on this mapstarted 2025, after this paper: background citation

The Effect of Physical Activity Levels on Dysmenorrhea Severity, Menstrual Symptoms, and Functional and Emotional Status in Women Diagnosed With Multiple Sclerosis

TypeobservationalSponsorKarabuk UniversityRan2025 to 2025Enrolled60ConditionsMultiple Sclerosis, Physical Activity, Dysmenorrhea, Emotional Disorder
3 · Its place in the literature

Who cites it

256 citing papers in PubMed, 9 syntheses or guidelines pooled it, 515 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Effects of natalizumab on oligoclonal bands in the cerebrospinal fluid of patients with multiple sclerosis: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Trial
  11. Trial
  12. Does M1 anodal transcranial direct current stimulation affects online and offline motor learning in patients with multiple sclerosis?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
    Trial
  13. Trial
  14. Article
  15. Article
  16. Female-enrichedbioRxiv : the preprint server for biology · 2026
    Article
  17. Review
  18. Article
  19. Review
  20. Article

196 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Hanne F HarboDepartment of Neurology, Oslo University Hospital, Ullevål and University of Oslo, 0407 Oslo, Norway.
Ralf Gold
Mar Tintoré
Oslo University Hospital · NORuhr University Bochum · DEUniversitat Autònoma de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS) is universally found to be more prevalent in women than men. This has led to extensive studies of differences in the immune system or nervous system between women and men, which might be caused by the effects of gonadal hormones, genetic differences, and different environmental exposures and modern lifestyle in men and women. We review the effects of sex and gender from a genetic, immunological and clinical point of view. We discuss the effects of sex on the clinical expression of MS and responses to therapy, as well as issues concerning pregnancy.

Indexed as

femalegenesimmunologyMultiple sclerosispregnancysex

Identifiers

PMID23858327
PMCPMC3707353
OpenAlexW2038054049

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.