ArticleTherapeutic advances in neurological disorders2013
Topiramate: Effects on cognition in patients with epilepsy, migraine headache and obesity.
Article in Therapeutic advances in neurological disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Memory Rehabilitation in Patients with Epilepsy: a Systematic Review.Neuropsychology review · 2018Pooled it
- Topiramate impairs cognitive function in methadone-maintained individuals with concurrent cocaine dependence.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2015Trial
- Guanfacine enhances inhibitory control and attentional shifting in early abstinent cocaine-dependent individuals.Journal of psychopharmacology (Oxford, England) · 2015Trial
- Zonisamide, topiramate, and levetiracetam: efficacy and neuropsychological effects in alcohol use disorders.Journal of clinical psychopharmacology · 2015Trial
- GRIK1 genotype moderates topiramate's effects on daily drinking level, expectations of alcohol's positive effects and desire to drink.The international journal of neuropsychopharmacology · 2014Trial
- Migraines and the association of cognitive impairment: a one- and two-sample mendelian randomization analysis.Dialogues in clinical neuroscience · 2026Article
- The Ketogenic Diet and Potential Micronutrient Risks in Drug-Resistant Epilepsy Management: A Literature Review.Nutrients · 2026Review
- Preoptic area influences sleep-related seizures in a genetic epilepsy mouse model.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Migraine and cognitive dysfunction: a narrative review.The journal of headache and pain · 2024Review
- Protective effects of topiramate on acetic acid-induced colitis in rats through the inhibition of oxidative stress.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Narrative Review of Topiramate: Clinical Uses and Pharmacological Considerations.Advances in therapy · 2023Review
- Targeting Autophagy, Apoptosis, and SIRT1/Nrf2 Axis with Topiramate Underlies Its Neuroprotective Effect against Cadmium-Evoked Cognitive Deficits in Rats.Pharmaceuticals (Basel, Switzerland) · 2023Article
- SipNose-topiramate: a potential novel approach to binge eating management.Journal of eating disorders · 2023Article
- Therapeutics for Substance-Using Women: The Need to Elucidate Sex-Specific Targets for Better-Tailored Treatments.Handbook of experimental pharmacology · 2023Article
- The Promising Effect of Topiramate on Random-Pattern Skin Flap Survival in Rats.Aesthetic plastic surgery · 2022Article
- Cognitive Dysfunction in Migraineurs.Medicina (Kaunas, Lithuania) · 2022Article
- Detecting Cognitive Impairment in Idiopathic Intracranial Hypertension Using Ocular Motor and Neuropsychological Testing.Frontiers in neurology · 2021Article
- Gastro protecting influence of Topiramate in ethanol produced gastric ulcers in rats.Toxicology reports · 2021Article
- Experimental Therapeutic Strategies in Epilepsies Using Anti-Seizure Medications.Journal of experimental pharmacology · 2021Review
- Topiramate Reverses Physiological and Behavioral Alterations by Postoperative Cognitive Dysfunction in Rat Model Through Inhibiting TNF Signaling Pathway.Neuromolecular medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper reviews the clinical implications of topiramate (TPM)-induced cognitive deficits in patients with epilepsy, migraine headache, obesity, and in normal populations, followed by reviews of the literature describing the reversal of such deficits upon medication discontinuation. It also discusses animal investigations of TPM's role of neuroprotection in brain injury. TPM's most intolerable adverse effects (AEs) are on verbal fluency and reaction time, resulting in high discontinuation rates in patients taking it for epilepsy and migraine headache. However, because TPM is so effective in the treatment of epilepsy and migraine headache, its use is expected to continue. There appears to be greater tolerance of TPM's cognitive AEs when it is used in the treatment of obesity, perhaps because of the lower doses required. Research attempting to predict the populations most vulnerable to the cognitive effects caused by TPM is ongoing. Studies suggest that one such population may include patients with a past psychiatric history. Slow titration and administration of the lowest possible doses may decrease risk of cognitive deficits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.