Evidence map›Paper›PMID 23857726›Full record

ReviewMacromolecular rapid communications2013

Responsive DNA-based hydrogels and their applications.

Xiangling Xiong, Cuichen Wu, Cuisong Zhou, Guizhi Zhu, Zhuo Chen, Weihong Tan

Abstract readReview
In one paragraph

Review in Macromolecular rapid communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Applications of DNA Hydrogels in Osteoporotic Bone Defects.Journal of functional biomaterials · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Aptamer-Modified Hydrogels.Advances in biochemical engineering/biotechnology · 2021
    Article
  13. Review
  14. DNA hydrogel-empowered biosensing.Advances in colloid and interface science · 2020
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Programmable hydrogels.Biomaterials · 2018
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiangling XiongDepartment of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, Center for Research at Bio/Nano Interface, University of Florida, Gainesville, FL 32611-7200, USA.
Cuichen Wu
Cuisong Zhou
Guizhi Zhu
Zhuo Chen
Weihong Tan

Funding

Development of molecular probes for biomedical applicationsR01GM079359 · NIGMS · UNIVERSITY OF FLORIDA · PI TAN, WEIHONG · 2007 to 2016
$2.3M
Real-Time and Quantitative Determination of GenesR01GM066137 · NIGMS · UNIVERSITY OF FLORIDA · PI TAN, WEIHONG · 2002 to 2010
$2.2M
Molecular Target for Liver Cancer Diagnosis and TherapyR01CA133086 · NCI · UNIVERSITY OF FLORIDA · PI LIU, CHEN · 2009 to 2013
$1.5M
NCI NIH HHS CA133086NCI NIH HHS R01 CA133086NIGMS NIH HHS GM066137NIGMS NIH HHS GM079359NIGMS NIH HHS R01 GM066137NIGMS NIH HHS R01 GM079359
6 · The paper itself

Abstract

The term hydrogel describes a type of soft and wet material formed by cross-linked hydrophilic polymers. The distinct feature of hydrogels is their ability to absorb a large amount of water and swell. The properties of a hydrogel are usually determined by the chemical properties of their constituent polymer(s). However, a group of hydrogels, called "smart hydrogels," changes properties in response to environmental changes or external stimuli. Recently, DNA or DNA-inspired responsive hydrogels have attracted considerable attention in construction of smart hydrogels because of the intrinsic advantages of DNA. As a biological polymer, DNA is hydrophilic, biocompatible, and highly programmable by Watson-Crick base pairing. DNA can form a hydrogel by itself under certain conditions, and it can also be incorporated into synthetic polymers to form DNA-hybrid hydrogels. Functional DNAs, such as aptamers and DNAzymes, provide additional molecular recognition capabilities and versatility. In this Review, DNA-based hydrogels are discussed in terms of their stimulus response, as well as their applications.

Indexed as

Aptamers, NucleotideBiocompatible MaterialsDNADNA, CatalyticDrug CarriersHydrogelsMetal NanoparticlesAptamers, NucleotideBiocompatible MaterialsDNADNA, CatalyticDrug CarriersHydrogelsbiological applications of polymersDNAhydrogelsresponsive

Identifiers

PMID23857726
PMCPMC4470902

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.