ArticleThe Journal of biological chemistry2013
Characterization of a nitrite reductase involved in nitrifier denitrification.
Article in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 48 citations in OpenAlex.
- Accurate atomic resolution XFEL structures of a metalloenzyme reveal key insights into its catalytic mechanism.Nature communications · 2026Article
- Synthetically Reversible, Proton-Mediated Nitrite N-O Bond Cleavage at a Dicopper Site.Journal of the American Chemical Society · 2024Article
- Nitrogen cycling activities during decreased stratification in the coastal oxygen minimum zone off Namibia.Frontiers in microbiology · 2023Article
- Complete Genome Sequencing of PolarInternational journal of microbiology · 2022Article
- Improving Nitrogen Use Efficiency in Aerobic Rice Based on Insights Into the Ecophysiology of Archaeal and Bacterial Ammonia Oxidizers.Frontiers in plant science · 2022Review
- Copper nitrite reductase from Sinorhizobium meliloti 2011: Crystal structure and interaction with the physiological versus a nonmetabolically related cupredoxin-like mediator.Protein science : a publication of the Protein Society · 2021Article
- Article
- Nitric Oxide Production from Nitrite Reduction and Hydroxylamine Oxidation by Copper-containing Dissimilatory Nitrite Reductase (NirK) from the Aerobic Ammonia-oxidizing Archaeon, Nitrososphaera viennensis.Microbes and environments · 2018Article
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- Is biochar-manure co-compost a better solution for soil health improvement and NSoil biology & biochemistry · 2017Article
- Design and evaluation of primers targeting genes encoding NO-forming nitrite reductases: implications for ecological inference of denitrifying communities.Scientific reports · 2016Article
- The Rise of Radicals in Bioinorganic Chemistry.Israel journal of chemistry · 2016Article
- Redox-coupled structural changes in nitrite reductase revealed by serial femtosecond and microfocus crystallography.Journal of biochemistry · 2016Article
- Redox-coupled proton transfer mechanism in nitrite reductase revealed by femtosecond crystallography.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Highly diverse nirK genes comprise two major clades that harbour ammonium-producing denitrifiers.BMC genomics · 2016Article
- Characterization of a nitrite-reducing octaheme hydroxylamine oxidoreductase that lacks the tyrosine cross-link.The Journal of biological chemistryArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitrifier denitrification is the conversion of nitrite to nitrous oxide by ammonia-oxidizing organisms. This process, which is distinct from denitrification, is active under aerobic conditions in the model nitrifier Nitrosomonas europaea. The central enzyme of the nitrifier dentrification pathway is a copper nitrite reductase (CuNIR). To understand how a CuNIR, typically inactivated by oxygen, functions in this pathway, the enzyme isolated directly from N. europaea (NeNIR) was biochemically and structurally characterized. NeNIR reduces nitrite at a similar rate to other CuNIRs but appears to be oxygen tolerant. Crystal structures of oxidized and reduced NeNIR reveal a substrate channel to the active site that is much more restricted than channels in typical CuNIRs. In addition, there is a second fully hydrated channel leading to the active site that likely acts a water exit pathway. The structure is minimally affected by changes in pH. Taken together, these findings provide insight into the molecular basis for NeNIR oxygen tolerance.
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