ArticleEuropean journal of clinical pharmacology2013
Persistence to antihypertensive drug treatment in Swedish primary healthcare.
Article in European journal of clinical pharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Long-Term Persistence and Treatment Changes of Antihypertensive Therapy: A 5-Year Cohort Study.Basic & clinical pharmacology & toxicology · 2026Article
- ADHD and adherence to antihypertensive medication treatment: a multinational cohort study.BMC medicine · 2026Article
- Real-World Effectiveness and Safety of Ramipril/Indapamide Combination Therapy in Essential Hypertension: A Retrospective Study on UK Primary Care Records.International journal of hypertension · 2026Article
- Contacts to general practitioners and renewal of antihypertensive medication - a four-year follow-up in primary health care, Turku, Finland.BMC primary care · 2025Article
- Socioeconomic Factors Associated with Non-Adherence to Antihypertensive Treatment Among Older Adults Affiliated to the "Pension 65" Program in Peru.Patient preference and adherence · 2025Article
- Use of common cardiovascular disease drugs and risk of dementia: A case-control study in Swedish national register data.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- A Qualitative Study on Patients' Views on Hypertension and Antihypertensive Medications.Patient preference and adherence · 2023Article
- Non-persistence to antihypertensive drug therapy in Lithuania.European journal of clinical pharmacology · 2022Article
- Initiation of antihypertensive drugs to patients with confirmed COVID-19-A population-based cohort study in Sweden.Basic & clinical pharmacology & toxicology · 2022Article
- Article
- Medication adherence among persons with coronary heart disease and associations with blood pressure and low-density-lipoprotein-cholesterol.European journal of clinical pharmacology · 2022Article
- Relationship Between Social Determinants of Health and Antihypertensive Medication Adherence in a Medicaid Cohort.Circulation. Cardiovascular quality and outcomes · 2022Article
- A Critical Review of Medication Adherence in Hypertension: Barriers and Facilitators Clinicians Should Consider.Patient preference and adherence · 2022Review
- Socioeconomic status affects achievement of blood pressure target in hypertension: contemporary results from the Swedish primary care cardiovascular database.Scandinavian journal of primary health care · 2021Article
- Relationship of an adherence score with blood pressure control status among patients with hypertension and their determinants: Findings from a nationwide blood pressure screening program.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Article
- Hypertension and Drug Adherence in the Elderly.Frontiers in cardiovascular medicine · 2020Review
- Persistence with treatment for Wilson disease: a retrospective study.BMC neurology · 2019Observational
- Medication Adherence In Patients With Arterial Hypertension: The Relationship With Healthcare Systems' Organizational Factors.Patient preference and adherence · 2019Article
- Is There a Threshold for Medication Adherence? Lessons Learnt From Electronic Monitoring of Drug Adherence.Frontiers in pharmacology · 2018Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo determine factors associated with low persistence in patients initiated on drug treatment for hypertension.
methodsCohort study using medical records for patients with hypertension in 48 Swedish primary healthcare centres. Data were linked to national registers on dispensed drugs, hospitalizations, outpatient hospital consultations, deaths, migration, and socioeconomy. We identified 5225 patients (55 % women, mean age 61 years) initiated on antihypertensive drug treatment during 2006-2007. Persistence was measured for two years by the dispensed drugs. Patients with a gap of >30 days between end of dispensed supply and the next dispensed prescription were classified as non-persistent. This was calculated by Kaplan-Meier analysis. Cox proportional hazard regression was used to estimate hazard ratios for discontinuation. Potential predictors included age, gender, blood pressure before initiation of therapy, cardiovascular comorbidity, educational level, country of birth, and income.
resultsAmong patients with a dispensed first prescription, 26 % discontinued treatment during the first year, and a further 9 % discontinued during the second year. Discontinuation (all adjusted) was more common in men (P = 0.002) and in younger patients (30-49 years, P < 0.001). Systolic (P < 0.001) but not diastolic blood pressure was positively associated with persistence. Native-born Swedish citizens and patients born in the other Nordic countries had lower discontinuation rates than those born outside the Nordic countries (P < 0.001).
conclusionMajor determinants of discontinuation of antihypertensive drug treatment are male sex, young age, mild-to-moderate systolic blood pressure elevation, and birth outside of Sweden.
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