SynthesisNutrients2013
The use of probiotic strains in caries prevention: a systematic review.
Synthesis in Nutrients, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 5 syntheses or guidelines pooled it, 178 citations in OpenAlex.
- Comparative effectiveness of probiotics, prebiotics, synbiotics, and postbiotics in preventing dental caries: a meta-analysis from an oral microbiota modulation perspective.BMC oral health · 2026Pooled it
- Postbiotics and Dental Caries: A Systematic Review.Clinical and experimental dental research · 2025Pooled it
- The role of probiotics in preventing dental caries: a systematic review of clinical evidence.Frontiers in oral health · 2025Pooled it
- Efficacy of Probiotic Consumption on Oral Outcomes in Children and/or Adolescents: A Meta-Analysis.International dental journal · 2024Pooled it
- Are dairy products containing probiotics beneficial for oral health? A systematic review and meta-analysis.Clinical oral investigations · 2018Pooled it
- Arginine Dentifrices and Childhood Caries Prevention: A Randomized Clinical Trial.JDR clinical and translational research · 2026Trial
- Effects of Probiotic Short-Term Regiment on Oral Health Parameters in Children: A Pilot Randomized Controlled Trial.Nutrients · 2025Trial
- Effect of a Short-Term Intervention withInternational journal of environmental research and public health · 2022Trial
- Significant elevation of salivary human neutrophil peptides 1-3 levels by probiotic milk in preschool children with severe early childhood caries: a randomized controlled trial.Clinical oral investigations · 2021Trial
- Efficiency of desensitizing materials in xerostomic patients with head and neck cancer: a comparative clinical study.Clinical oral investigations · 2020Trial
- Effects of a food enriched with probiotics on Streptococcus mutans and Lactobacillus spp. salivary counts in preschool children: a cluster randomized trial.Journal of applied oral science : revista FOB · 2018Trial
- Effect of probiotic chewing tablets on early childhood caries--a randomized controlled trial.BMC oral health · 2015Trial
- Enhancement of salivary human neutrophil peptide 1-3 levels by probiotic supplementation.BMC oral health · 2015Trial
- Probiotic Bifidobacterium animalis subsp. lactis BL-11 attenuates dental caries development in a Streptococcus mutans-induced rat model.Odontology · 2026Article
- Cariogenic Enamel Demineralization Prevention, Detection, and Management: A Literature Review.European journal of dentistry · 2026Article
- The effects of probiotics intervention on oral health outcomes: a comprehensive umbrella review of meta-analyses.Frontiers in oral health · 2026Review
- The strategic role of biotics in dental caries prevention: A scoping review.Food science & nutrition · 2024Article
- Chemical Characterization and Effect of a Lactobacilli-Postbiotic onMicroorganisms · 2024Article
- The role ofJournal of oral microbiology · 2024Review
- Manipulating the diseased oral microbiome: the power of probiotics and prebiotics.Journal of oral microbiology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper aims to provide a systematic review of the caries-prevention effect of probiotics in human. The hypothesis was that the administration of probiotic strains might play a role in caries lesion prevention and in the control of caries-related risk factors. The main relevant databases (Medline, Embase) were searched. Quality of the Randomized Clinical Trials (RCTs) was classified using the "Consolidated Standards of Reporting Trials" (CONSORT) checklist and the Impact Factor (IF) value of each journal was recorded. Sixty-six papers were identified, and 23 fulfilled the inclusion criteria. Only three studies had caries lesion development as outcome, all the others reported caries risk factors as interim evaluation. Using the CONSORT Score, the papers were coded as 4 excellent, 9 good and 10 poor. The mean IF value recorded was 1.438. Probiotics may play a role as antagonistic agent on mutans streptococci (MS), acidogenic/aciduric bacteria that contributes to the caries process. In two-thirds of the selected papers, probiotics have demonstrated the capacity to reduce MS counts in saliva and/or plaque in short-term. The effect of probiotics on the development of caries lesion seems encouraging, but to date, RCTs on this topic are insufficient to provide scientific clinical evidence.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.