Evidence map›Paper›PMID 23857078›Full record

ReviewMolecular bioSystems2013

Network representations and methods for the analysis of chemical and biochemical pathways.

Conner I Sandefur, Maya Mincheva, Santiago Schnell

Abstract readReview
In one paragraph

Review in Molecular bioSystems, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. What makes a reaction network "chemical"?Journal of cheminformatics · 2022
    Article
  3. A mechanism foreLife · 2020
    Article
  4. Article
  5. Article
  6. Article
  7. Energy-based analysis of biomolecular pathways.Proceedings. Mathematical, physical, and engineering sciences · 2017
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Conner I SandefurCystic Fibrosis and Pulmonary Diseases Research and Treatment Center and Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Maya Mincheva
Santiago Schnell

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Defining reaction mechanisms of threshold phenomena in conformational diseaseF31GM096728 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SANDEFUR, CONNER IKNOKWAYYO · 2011 to 2012
$47k
NIDDK NIH HHS P30 DK020572NIGMS NIH HHS F31 GM096728NIGMS NIH HHS F31GM0967728
6 · The paper itself

Abstract

Systems biologists increasingly use network representations to investigate biochemical pathways and their dynamic behaviours. In this critical review, we discuss four commonly used network representations of chemical and biochemical pathways. We illustrate how some of these representations reduce network complexity but result in the ambiguous representation of biochemical pathways. We also examine the current theoretical approaches available to investigate the dynamic behaviour of chemical and biochemical networks. Finally, we describe how the critical chemical and biochemical pathways responsible for emergent dynamic behaviour can be identified using network mining and functional mapping approaches.

Indexed as

Models, BiologicalAnimalsHumansSystems Biology

Identifiers

PMID23857078
PMCPMC3755892

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.