ReviewInternational journal of molecular medicine2013
Viral involvement in the pathogenesis and clinical features of ophthalmic pterygium (Review).
Review in International journal of molecular medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Evaluation of optical quality in pterygium patients with a new modified sutureless and glue-free method.BMC ophthalmology · 2021Trial
- The Potential Role of Vitamin D in the Pterygium Pathophysiology-A Possible New Therapeutic Perspective and Narrative Review.Journal of clinical medicine · 2025Review
- Potential Role ofInternational journal of molecular sciences · 2025Article
- Histone H3 lysine 9 tri-methylation is associated with pterygium.BMC ophthalmology · 2025Article
- Role of stress in the pathogenesis of cancer (Review).International journal of oncology · 2023Review
- Article
- Role of oncogenic viruses in the development ocular surface squamous neoplasia.International ophthalmology · 2021Article
- Association between HPV detection in swab samples and tissue specimens and ophthalmic pterygium recurrence.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Article
- Clinical demographics of pterygium excision and prevalence of conjunctival intraepithelial neoplasia: a 15-year review.International ophthalmology · 2020Article
- Pterygium Is Related to Short Axial Length.Cornea · 2020Article
- Prevalence of pterygium and its associated factors among adults aged 18 years and above in Gambella town, Southwest Ethiopia, May 2019.PloS one · 2020Article
- Paediatric virology and human papillomaviruses: An update.Experimental and therapeutic medicine · 2019Article
- Pyroptosis in pterygium pathogenesis.Bioscience reports · 2018Article
- Non-invasive detection of HPV DNA in exfoliative samples from ophthalmic pterygium: a feasibility study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2018Observational
- Letter to the Editor: Coinfection of Adenovirus with the Members of Herpesviridae in Ophthalmic Pterygium.The open microbiology journal · 2016Article
- Clinical Presentation of Ocular Surface Squamous Neoplasia in Kenya.JAMA ophthalmology · 2015Article
- Advances in Diagnosis and Treatment of HPV Ocular Surface Infections.Medical hypothesis, discovery & innovation ophthalmology journal · 2015Article
- Peroxiredoxin I and II in human eyes: cellular distribution and association with pterygium and DNA damage.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2014Article
- Pterygium: nonsurgical treatment using topical dipyridamole - a case report.Case reports in ophthalmology · 2014Article
- Pterygium: an update on pathophysiology, clinical features, and management.Therapeutic advances in ophthalmologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pterygium is a potentially vision-threatening fibrovascular lesion originating from the conjunctiva that often extends on the corneal surface. Although it has been extensively studied, its pathogenesis has yet to be fully elucidated. Recent evidence on molecular genetic abnormalities in pterygium suggested neoplastic changes of limbal stem cells potentially associated with exposure to ultraviolet (UV) light. Human papillomavirus (HPV) is an oncogenic virus, associated with squamo-proliferative lesions of the anogenital region, skin and oropharynx. Several studies have shown HPV involvement in the pathogenesis of conjunctival neoplastic lesions, including papilloma and squamous cell carcinoma. The involvement of HPV as a co-factor in the pathogenesis of pterygium, although suggested by several studies using PCR and immunohistochemical techniques, remains controversial. Moreover, a marked variation in the prevalence of HPV in ophthalmic pterygium has been reported by different studies. Ethnic susceptibility and methodological differences in the detection of HPV may account for this variation. Surgical excision, often using sophisticated techniques, is the standard current method of therapy for pterygium. However, recurrences are frequent and recurrent lesions tend to be more aggressive. If indeed HPV is involved in pterygium pathogenesis or recurrence, anti-viral medications or vaccination may be new options in pterygium therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.