Evidence map›Paper›PMID 23856897›Full record

ReviewExperimental biology and medicine (Maywood, N.J.)2013

Peptide and protein-based inhibitors of HIV-1 co-receptors.

Horst A von Recum, Jonathan K Pokorski

Open access · greenAbstract readReview
In one paragraph

Review in Experimental biology and medicine (Maywood, N.J.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Strategic Approaches to Improvise Peptide Drugs as Next Generation Therapeutics.International journal of peptide research and therapeutics · 2023
    Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Horst A von RecumDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Jonathan K Pokorski
Case Western Reserve University · US

Funding

Development of Protein-Displaying Peptide Hydrogels for Tissue EngineeringR00EB011530 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI POKORSKI, JONATHAN KYLE · 2012 to 2014
$716k
NIBIB NIH HHS R00 EB011530NIBIB NIH HHS R00EB011530
6 · The paper itself

Abstract

Human immunodeficiency virus (HIV) afflicts an estimated 30 million people globally, making it a continuing pandemic. Despite major research efforts, the rate of new infections has remained relatively static over time. This article reviews an emerging strategy for the treatment of HIV, the inhibition of the co-receptors necessary for HIV entry, CCR5 and CXCR4. The aim of this article is to highlight potential therapeutics derived from peptides and proteins that show particular promise in HIV treatment. Molecules that act on CCR5, CXCR4 or on both receptors will be discussed herein.

Indexed as

CCR5 Receptor AntagonistsHIV-1HIV InfectionsPandemicsAnimalsHIV Fusion InhibitorsHumansPeptidesReceptors, CXCR4Virus InternalizationCCR5 Receptor AntagonistsCXCR4 protein, humanHIV Fusion InhibitorsPeptidesReceptors, CXCR4CCR5CXCR4HIV

Identifiers

PMID23856897
PMCPMC3908444
OpenAlexW2061921276

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.