ArticleEarly human development2013
Early prediction of cerebral palsy after neonatal intensive care using motor development trajectories in infancy.
Article in Early human development, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Speech and language interventions for infants aged 0 to 2 years at high risk for cerebral palsy: a systematic review.Developmental medicine and child neurology · 2017Pooled it
- Early childhood constraint therapy for sensory/motor impairment in cerebral palsy: a randomised clinical trial protocol.BMJ open · 2015Trial
- Infants and Toddlers With Moderate-To-Severe Cerebral Palsy Receive Very Low Doses of In-Person Rehabilitation.Pediatric neurology · 2026Article
- Early detection of cerebral palsy among a high-risk cohort in Bangladesh.BMJ paediatrics open · 2025Article
- Differences in rehabilitation for high-risk newborns: The impact of neonatal intensive care unit hospitalization.PloS one · 2025Article
- Early Neurodevelopmental Assessments for Predicting Long-Term Outcomes in Infants at High Risk of Cerebral Palsy.JAMA network open · 2024Article
- Article
- Pairing taVNS and CIMT is feasible and may improve upper extremity function in infants.Frontiers in pediatrics · 2024Article
- The Benefits of Combining Bobath and Vojta Therapies in Infants with Motor Development Impairment-A Pilot Study.Medicina (Kaunas, Lithuania) · 2023Article
- Prediction of Perinatal and Neurodevelopmental Outcomes in Newborns with a Birth Weight below the 3rd Percentile: Performance of Two International Curves - Prospective Cohort from a Brazilian City.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2023Article
- A prospective study of neurodevelopmental trends between 3 and 24 months in normocephalic infants with prenatal Zika virus exposure: Evidence of emerging communication delays in the NATZIG cohort.Early human development · 2021Article
- Early Diagnostics and Early Intervention in Neurodevelopmental Disorders-Age-Dependent Challenges and Opportunities.Journal of clinical medicine · 2021Review
- Perspectives from the Society for Pediatric Research. Neonatal encephalopathy clinical trials: developing the future.Pediatric research · 2021Review
- The Predictive Accuracy of the General Movement Assessment for Cerebral Palsy: A Prospective, Observational Study of High-Risk Infants in a Clinical Follow-Up Setting.Journal of clinical medicine · 2019Article
- Hammersmith Infant Neurological Examination Asymmetry Score Distinguishes Hemiplegic Cerebral Palsy From Typical Development.Pediatric neurology · 2018Article
- Early, Accurate Diagnosis and Early Intervention in Cerebral Palsy: Advances in Diagnosis and Treatment.JAMA pediatrics · 2017Review
- Implementation of the Hammersmith Infant Neurological Examination in a High-Risk Infant Follow-Up Program.Pediatric neurology · 2016Article
- Increasing F2-isoprostanes in the first month after birth predicts poor respiratory and neurodevelopmental outcomes in very preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2016Observational
- Preclinical Models of Encephalopathy of Prematurity.Developmental neuroscience · 2015Review
- Abnormal sensory reactivity in preterm infants during the first year correlates with adverse neurodevelopmental outcomes at 2 years of age.Archives of disease in childhood. Fetal and neonatal edition · 2014Observational
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
unlabelledNeonatal intensive care unit (NICU) patients are at high risk for developmental disabilities such as cerebral palsy (CP). Early identification of CP is essential to effective rehabilitation, but diagnosis is often delayed, especially in preterm infants. We hypothesized that through the longitudinal evaluation of motor trajectories in the NICU follow-up clinic, we could distinguish infants who develop CP by 3 years of age. STUDY DESIGN AND SUBJECTS: This was a retrospective study of 606 patients in the NICU Follow-up Clinic at Vanderbilt University with birth weight < 1500g or a diagnosis of hypoxic ischemic encephalopathy. OUTCOMES MEASURES: Assessments included neurologic exams, the Developmental Assessment of Young Children (DAYC), the Bayley Scales of Infant Development (BSID) and the Gross Motor Function Classification Scale.
resultsA decrease in DAYC scores between 6 and 12 months was present in preterm and term infants later diagnosed with CP, but not in children without CP (-23 vs. +1.5, p<0.001). DAYC score decreases in infancy were highly predictive of later CP (p<0.001). BSID scores quantified severe motor delays but did not add to prediction of CP diagnosis.
conclusionStandardized assessments of motor milestones quantitatively predict the risk of CP in former NICU patients by 12 months, allowing for timely diagnosis, counseling and therapy in high-risk infants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.