ArticleBMC research notes2013
Co-operative inhibitory effects of hydrogen peroxide and iodine against bacterial and yeast species.
Article in BMC research notes, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 64 citations in OpenAlex.
- Photodynamic anti-biofilm PHEMA/Rose Bengal hydrogels enhanced by iodide: evidence for hydrogen peroxide and triiodide formation.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026Article
- Tactical use of irrigants in open orthopaedic procedures: 'what to use & when'.EFORT open reviews · 2026Review
- Methicillin-resistant Staphylococcus aureus (MRSA) infection of the temple region of the face: Case report.Medicine · 2025Article
- Antiseptics' Concentration, Combination, and Exposure Time on Bacterial and Fungal Biofilm Eradication.Arthroplasty today · 2024Article
- Impact of a Novel Antiseptic Lavage Solution on Acute Periprosthetic Joint Infection in Hip and Knee Arthroplasty.Journal of clinical medicine · 2024Article
- Application of the New Irrigation Protocol to Reduce Recurrence Rate in the Management Of Periprosthetic Joint Infection.Orthopaedic surgery · 2024Article
- Unveiling the super tolerance ofMicrobiology spectrum · 2024Article
- Deciphering the killing mechanisms of potassium iodide in combination with antimicrobial photodynamic therapy against cross-kingdom biofilm.Frontiers in cellular and infection microbiology · 2024Article
- Single-stage revision for chronic periprosthetic joint infection after knee and hip arthroplasties: indications and treatments.Arthroplasty (London, England) · 2023Review
- Development of a Polymeric Film Entrapping Rose Bengal and Iodide Anion for the Light-Induced Generation and Release of Bactericidal Hydrogen Peroxide.International journal of molecular sciences · 2022Article
- Cell Toxicity Study of Antiseptic Solutions Containing Povidone-Iodine and Hydrogen Peroxide.Diagnostics (Basel, Switzerland) · 2022Article
- Augmenting Azoles with Drug Synergy to Expand the Antifungal Toolbox.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Drug-dependent growth curve reshaping reveals mechanisms of antifungal resistance in Saccharomyces cerevisiae.Communications biology · 2022Article
- Irrigation Solutions in Total Joint Arthroplasty.Spartan medical research journal · 2022Article
- In Vitro Potentiation of Antimicrobial Photodynamic Inactivation by Addition of Potassium Iodide.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Reduced Susceptibility and Increased Resistance of Bacteria against Disinfectants: A Systematic Review.Microorganisms · 2021Review
- Wound Irrigation in Orthopedic Open Fractures: A Review.Surgical infections · 2021Review
- Pursuit of the ideal antiseptic irrigation solution in the management of periprosthetic joint infections.Journal of bone and joint infection · 2021Review
- Synergistic effect of fennel essential oil and hydrogen peroxide on bacterial biofilm.Postepy dermatologii i alergologii · 2020Article
- Oxygen-Independent Antimicrobial Photoinactivation: Type III Photochemical Mechanism?Antibiotics (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHydrogen peroxide and iodine are powerful antimicrobials widely used as antiseptics and disinfectants. Their antimicrobial properties are known to be enhanced by combining them with other compounds. We studied co-operative inhibitory activities (synergism, additive effects and modes of growth inhibition) of hydrogen peroxide and iodine used concurrently against 3 bacterial and 16 yeast species.
resultsSynergistic or additive inhibitory effects were shown for hydrogen peroxide and iodine mixtures against all 19 species used in the study. Both biocides were mostly cidal individually and in mixtures against Pseudomonas aeruginosa and Staphylococcus aureus. Both compounds manifested static inhibitory effects individually, but their mixtures were synergistically cidal for Saccharomyces cerevisiae and Escherihia coli. Cells of S. cerevisiae treated with hydrogen peroxide and iodine-hydrogen peroxide mixture produced increased numbers of respiratory deficient mutants indicating genotoxic effects.
conclusionIodine and hydrogen peroxide used concurrently interact synergistically or additively against a range of prokaryotic and eukaryotic microorganisms. The study provides an insight as to how these traditional antimicrobials could be used more effectively for disinfection and antisepsis. In addition, a simple approach is proposed for scoring genotoxicity of different biocides by using the budding yeast system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.