ArticleVirology journal2013
Phylogeography and evolutionary history of hepatitis B virus genotype F in Brazil.
Article in Virology journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- From Genome Diversity to Inferred Functional Constraints: An Integrated Evolutionary Analysis of Hepatitis B Virus Genotype F.International journal of molecular sciences · 2026Article
- First Detection of Hepatitis B Virus Subgenotype A5, and Characterization of Occult Infection and Hepatocellular Carcinoma-Related Mutations in Latin American and African Immigrants in Brazil.International journal of molecular sciences · 2024Article
- Genetic variability of hepatitis B virus in acute and in different phases of chronic infection in Brazil.Scientific reports · 2024Article
- Article
- Hepatitis B Virus Infection among Japanese Immigrants and Descendants: The Need to Strengthen Preventive and Control Measures.Viruses · 2022Article
- Recent molecular evolution of hepatitis B virus genotype F in Latin America.Archives of virology · 2022Article
- Article
- Hepatitis B in the Northwestern region of Sao Paulo State: genotypes and resistance mutations.Revista do Instituto de Medicina Tropical de Sao Paulo · 2021Article
- Article
- Reconstruction of the spatial and temporal dynamics of hepatitis B virus genotype D in the Americas.PloS one · 2019Article
- Insights From Deep Sequencing of the HBV Genome-Unique, Tiny, and Misunderstood.Gastroenterology · 2019Review
- Phylogenetic analysis and genotype distribution of Hepatitis B Virus (HBV) in Roraima, Brazil.Revista do Instituto de Medicina Tropical de Sao Paulo · 2018Article
- Phylogeographic analysis of the full genome of Sweepovirus to trace virus dispersal and introduction to Korea.PloS one · 2018Article
- A Relaxed Directional Random Walk Model for Phylogenetic Trait Evolution.Systematic biology · 2017Article
- Enigmatic origin of hepatitis B virus: an ancient travelling companion or a recent encounter?World journal of gastroenterology · 2014Review
- Hepatitis B virus infection in Latin America: a genomic medicine approach.World journal of gastroenterology · 2014Review
- Distribution of HBV subgenotypes in Ribeirão Preto, Southeastern Brazil: a region with history of intense Italian immigration.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHepatitis B virus (HBV) genotype F (HBV/F) is considered to be indigenous to the Americas, but its emergence and spread in the continent remain unknown. Previously, only two HBV/F complete genome sequences from Brazil were available, limiting the contribution of Brazilian isolates to the phylogenetic studies of HBV/F. The present study was carried out to assess the proportion and geographic distributions of HBV/F subgenotypes in Brazil, to determine the full-length genomic sequences of HBV/F isolates from different Brazilian geographic regions, and to investigate the detailed evolutionary history and phylogeography of HBV/F in Brazil.
methodsComplete HBV/F genomes isolated from 12 Brazilian patients, representing the HBV/F subgenotypes circulating in Brazil, were sequenced and analyzed together with sequences retrieved from GenBank, using the Bayesian coalescent and phylogeographic framework.
resultsPhylogenetic analysis using all Brazilian HBV/F S-gene sequences available in GenBank showed that HBV/F2a is found at higher frequencies countrywide and corresponds to all sequences isolated in the Brazilian Amazon Basin. In addition, the evolutionary analysis using complete genome sequences estimated an older median ancestral age for the Brazilian HBV/F2a compared to the Brazilian HBV/F1b and HBV/F4 subgenotypes, suggesting that HBV/F2a represents the original native HBV of Brazil. The phylogeographic patterns suggested a north-to-south flow of HBV/F2a from Venezuela to Brazil, whereas HBV/F1b and HBV/F4 strains appeared to have spread from Argentina to Brazil.
conclusionsThis study suggests a plausible route of introduction of HBV/F subgenotypes in Brazil and demonstrates the usefulness of recently developed computational tools for investigating the evolutionary history of HBV.
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