ArticleBMC microbiology2013
Widespread acquisition of antimicrobial resistance among Campylobacter isolates from UK retail poultry and evidence for clonal expansion of resistant lineages.
Article in BMC microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Genomic epidemiology and the evolution ofMicrobial genomics · 2025Article
- Whole-genome-based characterization ofMicrobial genomics · 2023Article
- Prevalence and genomic characterization ofFrontiers in microbiology · 2023Article
- Erythromycin resistance of clinicalFrontiers in microbiology · 2023Article
- Emerging patterns of fluoroquinolone resistance inMicrobial genomics · 2022Article
- Metaphenotypes associated with recurrent genomic lineages ofFrontiers in microbiology · 2022Article
- Genome and Methylome analysis of a phylogenetic novelMicrobial genomics · 2021Article
- The Fate of Foodborne Pathogens in Manure Treated Soil.Frontiers in microbiology · 2021Review
- Antimicrobial resistance patterns and molecular resistance markers of Campylobacter jejuni isolates from human diarrheal cases.PloS one · 2020Article
- Investigating Major RecurringFrontiers in cellular and infection microbiology · 2020Article
- Article
- Nationwide Stepwise Emergence and Evolution of Multidrug-Resistant Campylobacter jejuni Sequence Type 5136, United Kingdom.Emerging infectious diseases · 2019Article
- Antimicrobial resistance genes in Salmonella and Escherichia coli isolates from chicken droppings in Nairobi, Kenya.BMC research notes · 2019Article
- Population genomics of bacterial host adaptation.Nature reviews. Genetics · 2018Review
- Convergent Amino Acid Signatures in Polyphyletic Campylobacter jejuni Subpopulations Suggest Human Niche Tropism.Genome biology and evolution · 2018Article
- Prevalence of Genetic Determinants and Phenotypic Resistance to Ciprofloxacin inFrontiers in microbiology · 2018Article
- Trends in fluoroquinolone resistance in Campylobacter.Microbial genomics · 2018Article
- Local genes for local bacteria: Evidence of allopatry in the genomes of transatlantic Campylobacter populations.Molecular ecology · 2017Article
- Detection and prevalence of antimicrobial resistance genes inThe Onderstepoort journal of veterinary research · 2017Article
- Prevalence and antimicrobial resistance of Campylobacter jejuni and Campylobacter coli isolated from children and environmental sources in urban and suburban areas.BMC microbiology · 2017Article
Corrections and comments
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9 authors.
Funding
Abstract
backgroundAntimicrobial resistance is increasing among clinical Campylobacter cases and is common among isolates from other sources, specifically retail poultry - a major source of human infection. In this study the antimicrobial susceptibility of isolates from a UK-wide survey of Campylobacter in retail poultry in 2001 and 2004-5 was investigated. The occurrence of phenotypes resistant to tetracycline, quinolones (ciprofloxacin and naladixic acid), erythromycin, chloramphenicol and aminoglycosides was quantified. This was compared with a phylogeny for these isolates based upon Multi Locus Sequence Typing (MLST) to investigate the pattern of antimicrobial resistance acquisition.
resultsAntimicrobial resistance was present in all lineage clusters, but statistical testing showed a non-random distribution. Erythromycin resistance was associated with Campylobacter coli. For all antimicrobials tested, resistant isolates were distributed among relatively distant lineages indicative of widespread acquisition. There was also evidence of clustering of resistance phenotypes within lineages; indicative of local expansion of resistant strains.
conclusionsThese results are consistent with the widespread acquisition of antimicrobial resistance among chicken associated Campylobacter isolates, either through mutation or horizontal gene transfer, and the expansion of these lineages as a proportion of the population. As Campylobacter are not known to multiply outside of the host and long-term carriage in humans is extremely infrequent in industrialized countries, the most likely location for the proliferation of resistant lineages is in farmed chickens.
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