ArticleBMC genomics2013
Variable promoter methylation contributes to differential expression of key genes in human placenta-derived venous and arterial endothelial cells.
Article in BMC genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Transcriptional and Epigenomic Markers of the Arterial-Venous and Micro/Macro-Vascular Endothelial Heterogeneity within the Umbilical-Placental Bed.International journal of molecular sciences · 2022Pooled it
- Epigenome-Wide Search for Distinctive Methylation Biomarkers of Endothelial and Leukocyte DNA.Epigenomes · 2025Article
- Nicotinic Acid-Mediated Modulation of Metastasis-Associated Protein 1 Methylation and Inflammation in Brain Arteriovenous Malformation.Biomolecules · 2023Article
- Specific arterio-venous transcriptomic and ncRNA-RNA interactions in human umbilical endothelial cells: A meta-analysis.iScience · 2021Article
- Transcriptomic Remodelling of Fetal Endothelial Cells During Establishment of Inflammatory Memory.Frontiers in immunology · 2021Article
- Perinatal Derivatives: Where Do We Stand? A Roadmap of the Human Placenta and Consensus for Tissue and Cell Nomenclature.Frontiers in bioengineering and biotechnology · 2020Review
- Article
- H3K27 acetylation and gene expression analysis reveals differences in placental chromatin activity in fetal growth restriction.Clinical epigenetics · 2018Article
- The impact of P2Y12 promoter DNA methylation on the recurrence of ischemic events in Chinese patients with ischemic cerebrovascular disease.Scientific reports · 2016Article
- Genetic and epigenetic mechanisms in the development of arteriovenous malformations in the brain.Clinical epigenetics · 2016Review
- Role of the fetoplacental endothelium in fetal growth restriction with abnormal umbilical artery Doppler velocimetry.American journal of obstetrics and gynecology · 2015Review
- Multigenerational epigenetic inheritance in humans: DNA methylation changes associated with maternal exposure to lead can be transmitted to the grandchildren.Scientific reports · 2015Article
- A role for GPR55 in human placental venous endothelial cells.Histochemistry and cell biology · 2015Article
- Clinical applications of epigenetics in cardiovascular disease: the long road ahead.Translational research : the journal of laboratory and clinical medicine · 2015Review
- Endothelial heterogeneity in the umbilico-placental unit: DNA methylation as an innuendo of epigenetic diversity.Frontiers in pharmacology · 2014Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe endothelial compartment, comprising arterial, venous and lymphatic cell types, is established prenatally in association with rapid phenotypic and functional changes. The molecular mechanisms underpinning this process in utero have yet to be fully elucidated. The aim of this study was to investigate the potential for DNA methylation to act as a driver of the specific gene expression profiles of arterial and venous endothelial cells.
resultsPlacenta-derived venous and arterial endothelial cells were collected at birth prior to culturing. DNA methylation was measured at >450,000 CpG sites in parallel with expression measurements taken from 25,000 annotated genes. A consistent set of genomic loci was found to show coordinate differential methylation between the arterial and venous cell types. This included many loci previously not investigated in relation to endothelial function. An inverse relationship was observed between gene expression and promoter methylation levels for a limited subset of genes implicated in endothelial function, including NOS3, encoding endothelial Nitric Oxide Synthase.
conclusionEndothelial cells derived from the placental vasculature at birth contain widespread methylation of key regulatory genes. These are candidates involved in the specification of different endothelial cell types and represent potential target genes for environmentally mediated epigenetic disruption in utero in association with cardiovascular disease risk later in life.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.