Evidence map›Paper›PMID 23855603›Full record

ReviewAnnals of the New York Academy of Sciences2013

RNA polymerase: in search of promoters.

Andrey Feklistov

Open access · greenAbstract readReview
In one paragraph

Review in Annals of the New York Academy of Sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. RNAP Promoter Search and Transcription Kinetics in LiveThe journal of physical chemistry. B · 2023
    Article
  5. σMicrobiology spectrum · 2022
    Article
  6. Construction of Strong Promoters by Assembling Sigma Factor Binding Motifs.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Andrey FeklistovLaboratory of Molecular Biophysics, The Rockefeller University, New York, New York 10065, USA. afeklistov@rockefeller.edu
Rockefeller University · US

Funding

E COLI RNA POLYMERASE SUBUNIT--STRUCTURE/FUNCTIONR01GM053759 · NIGMS · ROCKEFELLER UNIVERSITY · PI DARST, SETH A. · 1996 to 2015
$6.9M
NIGMS NIH HHS R01 GM053759
6 · The paper itself

Abstract

Transcription initiation is a key event in the regulation of gene expression. RNA polymerase (RNAP), the central enzyme of transcription, is able to efficiently locate promoters in the genome, carry out promoter opening, and initiate RNA synthesis. All the substeps of transcription initiation are subject to complex cellular regulation. Understanding the molecular details of each step in the promoter-opening pathway is essential for a complete mechanistic and quantitative picture of gene expression. In this minireview, primarily using bacterial RNAP as an example, I briefly summarize some of the key recent advances in our understanding of the mechanisms of promoter search and promoter opening.

Indexed as

Models, MolecularPromoter Regions, GeneticTranscription, GeneticAnimalsBacterial ProteinsDNADNA, BacterialDNA-Directed RNA PolymerasesDNA, Single-StrandedHumansMolecular ConformationSigma FactorBacterial ProteinsDNADNA, BacterialDNA-Directed RNA PolymerasesDNA, Single-StrandedSigma Factorpromoterprotein-DNA recognitionRNA polymerasetranscription

Identifiers

PMID23855603
PMCPMC3740395
OpenAlexW1552768340

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.