ArticleAnalytical chemistry2013
Multicomponent chemical imaging of pharmaceutical solid dosage forms with broadband CARS microscopy.
Article in Analytical chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 60 citations in OpenAlex.
- Coherent Raman Scattering Microscopy in Oncology Pharmacokinetic Research.Frontiers in pharmacology · 2021Review
- Portable all-fiber dual-output widely tunable light source for coherent Raman imaging.Biomedical optics express · 2019Article
- Understanding Dissolution and Crystallization with Imaging: A Surface Point of View.Molecular pharmaceutics · 2018Article
- Dynamic Sparse Sampling for Confocal Raman Microscopy.Analytical chemistry · 2018Article
- Fast epi-detected broadband multiplex CARS and SHG imaging of mouse skull cells.Biomedical optics express · 2018Article
- Application of UV Imaging in Formulation Development.Pharmaceutical research · 2017Review
- Molecular imaging with CARS micro-spectroscopy.Current opinion in chemical biology · 2016Review
- In Situ and In Vivo Molecular Analysis by Coherent Raman Scattering Microscopy.Annual review of analytical chemistry (Palo Alto, Calif.) · 2016Article
- Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
We compare a coherent Raman imaging modality, broadband coherent anti-Stokes Raman scattering (BCARS) microscopy, with spontaneous Raman microscopy for quantitative and qualitative assessment of multicomponent pharmaceuticals. Indomethacin was used as a model active pharmaceutical ingredient (API) and was analyzed in a tabulated solid dosage form, embedded within commonly used excipients. In comparison with wide-field spontaneous Raman chemical imaging, BCARS acquired images 10× faster, at higher spatiochemical resolution and with spectra of much higher SNR, eliminating the need for multivariate methods to identify chemical components. The significant increase in spatiochemical resolution allowed identification of an unanticipated API phase that was missed by the spontaneous wide-field method and bulk Raman spectroscopy. We confirmed the presence of the unanticipated API phase using confocal spontaneous Raman, which provided spatiochemical resolution similar to BCARS but at 100× slower acquisition times.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.