ArticleBMC infectious diseases2013
Seroepidemiology of human enterovirus71 and coxsackievirusA16 among children in Guangdong province, China.
Article in BMC infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Seroprevalence of coxsackievirus A6 and enterovirus A71 infection in humans: a systematic review and meta-analysis.Archives of virology · 2023Pooled it
- Seroprevalence of Enterovirus 71 Antibody Among Children in China: A Systematic Review and Meta-analysis.The Pediatric infectious disease journal · 2015Pooled it
- Clinical characteristics and severity of hand, foot, and mouth disease by virus serotype: A prospective hospital-based cohort study.PLoS neglected tropical diseases · 2025Article
- Seroprevalence of human enterovirus A71 in Guangzhou, China, 2019-2021.Biosafety and health · 2023Article
- Molecular surveillance of coxsackievirus A16 in southern China, 2008-2019.Archives of virology · 2021Article
- Phylogenetic characteristics and molecular epidemiological analysis of novel enterovirus EV-B83 isolated from Tibet, China.Scientific reports · 2020Article
- Incidence of Infection of Enterovirus 71 and Coxsackieviruses A6 and A16 among Household Contacts of Index Cases in Dong Thap Province, Southern Vietnam.BioMed research international · 2020Article
- Tracking echovirus eleven outbreaks in Guangdong, China: a metatranscriptomic, phylogenetic, and epidemiological study.Virus evolution · 2020Article
- Transmission and serotype features of hand foot mouth disease in household contacts in Dong Thap, Vietnam.BMC infectious diseases · 2019Article
- A Simple Scoring System for Quick, Accurate, and Reliable Early Diagnosis of Hand, Foot, and Mouth Disease.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Non-neutralizing Antibody Responses against VP1 in Enterovirus A, B, C and Rhinovirus A species among Infants and Children in Shanghai.Scientific reports · 2018Article
- Quantifying the influence of temperature on hand, foot and mouth disease incidence in Wuhan, Central China.Scientific reports · 2018Article
- Serological survey of neutralizing antibodies to eight major enteroviruses among healthy population.Emerging microbes & infections · 2018Article
- Phylogenetic Characterizations of Highly Mutated EV-B106 Recombinants Showing Extensive Genetic Exchanges with Other EV-B in Xinjiang, China.Scientific reports · 2017Article
- Economic costs and health-related quality of life for hand, foot and mouth disease (HFMD) patients in China.PloS one · 2017Article
- Cyclical Patterns of Hand, Foot and Mouth Disease Caused by Enterovirus A71 in Malaysia.PLoS neglected tropical diseases · 2016Article
- Seroprevalence of Enterovirus A71 and Coxsackievirus A16 in Healthy People in Shandong Province, China.PloS one · 2016Article
- Risk Factors for Enterovirus A71 Seropositivity in Rural Indigenous Populations in West Malaysia.PloS one · 2016Article
- Development and characterization of a clinical strain of Coxsackievirus A16 and an eGFP infectious clone.Virologica Sinica · 2015Article
- Phylogenetic analysis of the major causative agents of hand, foot and mouth disease in Suzhou City, Jiangsu province, China, in 2012-2013.Emerging microbes & infections · 2015Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHand, foot and mouth disease (HFMD) is a common pediatric illness. Mainly induced by the Enterovirus 71 and Coxsackievirus A 16 infections, the frequently occurred HFMD outbreaks have become a serious public health problem in Southeast Asia. Currently,only a few studies have investigated the human immunity to HFMD in China. In this study, we conducted a cohort study in Guangdong province, China.
methodsStored serum samples from children less than 10 years old were analyzed. The levels of EV71 and CA16 specific antibodies before, during and shortly after the 2008 large outbreak of HFMD were evaluated by the microneutralization test. The geometric mean titer (GMT) was calculated and compared. Statistical significance was taken as P < 0.05.
resultsThe seroprevalence data showed a continuous circulation of EV71 and CA16 in Guangdong province China in 2007-2009. The low positive rate in 2009 correlated well with the unprecedented outbreak of HFMD in 2010. Age related increase of seroprevalence was identified in 1-3 years old children for EV71 and in 1-5 years old children for CA16 in Guangdong province. High GMT of EV71 and CA16 antibody titers were also found for these age groups.
conclusionsAll of the above findings indicated common infections for these age groups. And they should clearly be at the top of the priority in periodical seroprevalence survey and future vaccination campaign.
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