ReviewJournal of gastroenterology and hepatology2013
Hepatic stellate cells, liver innate immunity, and hepatitis C virus.
Review in Journal of gastroenterology and hepatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 54 citations in OpenAlex.
- Characterization of changes in intrahepatic immune cell populations during HCV treatment with sofosbuvir and ribavirin.Journal of viral hepatitis · 2019Trial
- Pancreatic Ductal Adenocarcinoma After Hepatitis C Infection.JAMA network open · 2025Article
- NiCo identifies extrinsic drivers of cell state modulation by niche covariation analysis.Nature communications · 2024Article
- KLF4 Inhibits the Activation of Human Hepatic Stellate Cell In Vitro.Current medical science · 2024Article
- Physiomimetic In Vitro Human Models for Viral Infection in the Liver.Seminars in liver disease · 2023Review
- Article
- Physiologically relevant microsystems to study viral infection in the human liver.Frontiers in microbiology · 2022Review
- Review
- Intracellular Accumulation of IFN-λ4 Induces ER Stress and Results in Anti-Cirrhotic but Pro-HCV Effects.Frontiers in immunology · 2021Article
- Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids.Cell metabolism · 2019Article
- Retinoids in Stellate Cells: Development, Repair, and Regeneration.Journal of developmental biology · 2019Review
- Adiponectin inhibits hepatic stellate cell activation by targeting the PTEN/AKT pathway.Biochimica et biophysica acta. Molecular basis of disease · 2018Article
- Comparative proteomic analysis revealed complex responses to classical/novel duck reovirus infections in Cairna moschata.Scientific reports · 2018Article
- Analysis of Plasma Tenascin-C in Post-HCV Cirrhosis: A Prospective Study.Digestive diseases and sciences · 2018Article
- TLR3 Activation of Hepatic Stellate Cell Line Suppresses HBV Replication in HepG2 Cells.Frontiers in immunology · 2018Article
- Intrahepatic regulation of antiviral T cell responses at initial stages of viral infection.International immunopharmacology · 2016Review
- Influence of cytokine and cytokine receptor gene polymorphisms on the degree of liver damage in patients with chronic hepatitis C.Meta gene · 2016Article
- Progress in the development of vaccines for hepatitis C virus infection.World journal of gastroenterology · 2015Review
- Acetaldehyde accelerates HCV-induced impairment of innate immunity by suppressing methylation reactions in liver cells.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- Liver fibrosis occurs through dysregulation of MyD88-dependent innate B-cell activity.Hepatology (Baltimore, Md.) · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Chronic hepatitis C virus (HCV) infection can cause liver damage, ranging from mild to more severe conditions, such as fibrosis and cirrhosis. Hepatic stellate cell (HSC) activation is a key event in HCV-induced liver fibrosis. HSCs express several HCV coreceptors that interact with HCV proteins, promoting liver fibrogenesis. In addition, HSCs have the ability to engulf apoptotic bodies of hepatocytes induced by HCV and trigger a profibrogenic response. Recent studies have suggested that HSCs may play a novel role in the liver innate immunity. HSCs enhanced differentiation and accumulation of regulatory T cells. HSCs-activated natural killer cells could produce γ-interferon that inhibits HCV replication. Importantly, HSCs possess functional Toll-like receptor-3 and retinoic acid-inducible gene I that can be activated by their ligands (poly I :C, 5'ppp-dsRNA), leading to the induction of interferon and inhibition of HCV replication in hepatocytes. These new observations highlight the importance of HSCs in liver immunity against HCV, which is the focus of this review paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.