ArticleBiomicrofluidics2012
Microfluidic impedance spectroscopy as a tool for quantitative biology and biotechnology.
Article in Biomicrofluidics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Microplastic Identification Methods for Microfluidic Applications: Towards Rapid Detection in Aquatic Environments.Polymers · 2026Review
- Structural, Compositional, and Dielectric State Profiling in Label-Free Single-Cell Monitoring.Small methods · 2026Review
- Microfluidic platform for understanding Parkinson's disease and α-synuclein conformation.Translational neurodegeneration · 2025Review
- A Label-Free Electrical Impedance Spectroscopy for Detection of Clusters of Extracellular Vesicles Based on Their Unique Dielectric Properties.Biosensors · 2022Article
- Dielectric Spectroscopy Based Detection of Specific and Nonspecific Cellular Mechanisms.Sensors (Basel, Switzerland) · 2021Article
- Characterization of Single-Nucleus Electrical Properties by Microfluidic Constriction Channel.Micromachines · 2019Article
- Use of Surface-Enhanced Raman Scattering (SERS) Probes to Detect Fatty Acid Receptor Activity in a Microfluidic Device.Sensors (Basel, Switzerland) · 2019Article
- Selective Detection of Human Lung Adenocarcinoma Cells Based on the Aptamer-Conjugated Self-Assembled Monolayer of Gold Nanoparticles.Micromachines · 2019Article
- Label-free detection of conformational changes in switchable DNA nanostructures with microwave microfluidics.Nature communications · 2019Article
- An Aptamer-Based Capacitive Sensing Platform for Specific Detection of Lung Carcinoma Cells in the Microfluidic Chip.Biosensors · 2018Article
- Adrenal Chromaffin Cells Exposed to 5-ns Pulses Require Higher Electric Fields to Porate Intracellular Membranes than the Plasma Membrane: An Experimental and Modeling Study.The Journal of membrane biology · 2017Article
- Response to Alternating Electric Fields of Tubulin Dimers and Microtubule Ensembles in Electrolytic Solutions.Scientific reports · 2017Article
- Dielectrophoresis assisted loading and unloading of microwells for impedance spectroscopy.Electrophoresis · 2017Article
- Application of Vertical Electrodes in Microfluidic Channels for Impedance Analysis.Micromachines · 2016Article
- Platinum black electrodeposited thread based electrodes for dielectrophoretic assembly of microparticles.Biomicrofluidics · 2016Article
- Differential dielectric responses of chondrocyte and Jurkat cells in electromanipulation buffers.Electrophoresis · 2015Article
- Microfluidic platform for assessing pancreatic islet functionality through dielectric spectroscopy.Biomicrofluidics · 2015Article
- Microfluidic impedance flow cytometry enabling high-throughput single-cell electrical property characterization.International journal of molecular sciences · 2015Review
- Protein dielectrophoresis and the link to dielectric properties.Bioanalysis · 2015Review
- Microfluidic impedance cytometry of tumour cells in blood.Biomicrofluidics · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A microfluidic device that is able to perform dielectric spectroscopy is developed. The device consists of a measurement chamber that is 250 μm thick and 750 μm in radius. Around 1000 cells fit inside the chamber assuming average quantities for cell radius and volume fraction. This number is about 1000 folds lower than the capacity of conventional fixtures. A T-cell leukemia cell line Jurkat is tested using the microfluidic device. Measurements of deionized water and salt solutions are utilized to determine parasitic effects and geometric capacitance of the device. Physical models, including Maxwell-Wagner mixture and double shell models, are used to derive quantities for sub-cellular units. Clausius-Mossotti factor of Jurkat cells is extracted from the impedance spectrum. Effects of cellular heterogeneity are discussed and parameterized. Jurkat cells are also tested with a time domain reflectometry system for verification of the microfluidic device. Results indicate good agreement of values obtained with both techniques. The device can be used as a unique cell diagnostic tool to yield information on sub-cellular units.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.