ArticleBiomicrofluidics2012
Microfluidic separation of live and dead yeast cells using reservoir-based dielectrophoresis.
Article in Biomicrofluidics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Dielectric double shell characterization of yeast cells exposed to simulated microgravity.NPJ microgravity · 2026Article
- A Smartphone-Driven Acoustic Platform for Non-Invasive Modulation of Cellular Behavior in Microfluidic Channels.Micromachines · 2026Article
- Selective Detection ofNanomaterials (Basel, Switzerland) · 2023Article
- Modified Red Blood Cells as Multimodal Standards for Benchmarking Single-Cell Cytometry and Separation Based on Electrical Physiology.Analytical chemistry · 2022Article
- Particle trapping in electrically driven insulator-based microfluidics: Dielectrophoresis and induced-charge electrokinetics.Electrophoresis · 2021Review
- Modeling Brownian Microparticle Trajectories in Lab-on-a-Chip Devices with Time Varying Dielectrophoretic or Optical Forces.Micromachines · 2021Article
- Characterization and Separation of Live and Dead Yeast Cells Using CMOS-Based DEP Microfluidics.Micromachines · 2021Article
- Microbial Community Characteristics Largely Unaffected by X-Ray Computed Tomography of Sediment Cores.Frontiers in microbiology · 2021Article
- Dielectrophoretic Immobilization of Yeast Cells Using CMOS Integrated Microfluidics.Micromachines · 2020Article
- Label-free enrichment of fate-biased human neural stem and progenitor cells.Biosensors & bioelectronics · 2020Article
- Dielectrophoresis of Amyloid-Beta Proteins as a Microfluidic Template for Alzheimer's Research.International journal of molecular sciences · 2019Article
- Sorting by interfacial tension (SIFT): label-free selection of live cells based on single-cell metabolism.Lab on a chip · 2019Article
- Bridging the scales in high-throughput dielectrophoretic (bio-)particle separation in porous media.Scientific reports · 2018Article
- Continuous-Flow Cell Dipping and Medium Exchange in a Microdevice using Dielectrophoresis.Micromachines · 2018Article
- Three-Dimensional Reservoir-Based Dielectrophoresis (rDEP) for Enhanced Particle Enrichment.Micromachines · 2018Article
- Dielectrophoretic Separation of Live and Dead Monocytes Using 3D Carbon-Electrodes.Sensors (Basel, Switzerland) · 2017Article
- Dielectrophoretic force measurement of red blood cells exposed to oxidative stress using optical tweezers and a microfluidic chip.Biomedical engineering letters · 2017Article
- Microfluidic Sorting of Cells by Viability Based on Differences in Cell Stiffness.Scientific reports · 2017Article
- Particle concentrating and sorting under a rotating electric field by direct optical-liquid heating in a microfluidics chip.Biomicrofluidics · 2017Article
- Dielectrophoresis for Biomedical Sciences Applications: A Review.Sensors (Basel, Switzerland) · 2017Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Separating live and dead cells is critical to the diagnosis of early stage diseases and to the efficacy test of drug screening, etc. This work demonstrates a novel microfluidic approach to dielectrophoretic separation of yeast cells by viability. It exploits the cell dielectrophoresis that is induced by the inherent electric field gradient at the reservoir-microchannel junction to selectively trap dead yeast cells and continuously separate them from live ones right inside the reservoir. This approach is therefore termed reservoir-based dielectrophoresis (rDEP). It has unique advantages as compared to existing dielectrophoretic approaches such as the occupation of zero channel space and the elimination of any mechanical or electrical parts inside microchannels. Such an rDEP cell sorter can be readily integrated with other components into lab-on-a-chip devices for applications to biomedical diagnostics and therapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.