ArticleJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2012
Effect of mebudipine on oxidative stress and lipid peroxidation in myocardial ischemic-reperfusion injury in male rat.
Article in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 23 citations in OpenAlex.
- Ameliorative effect of taurine-chloramine in azathioprine-induced testicular damage; a deeper insight into the mechanism of protection.BMC complementary and alternative medicine · 2018Article
- 1,4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues-Model Compounds Targeting Oxidative Stress.Oxidative medicine and cellular longevity · 2016Review
- Correlation between vitamin D levels and muscle fatigue risk factors based on physical activity in healthy older adults.Clinical interventions in aging · 2016Article
- Contribution of apoptosis in myocardial reperfusion injury and loss of cardioprotection in diabetes mellitus.The journal of physiological sciences : JPS · 2015Review
- Beneficial effect of troxerutin on diabetes-induced vascular damages in rat aorta: histopathological alterations and antioxidation mechanism.International journal of endocrinology and metabolism · 2015Article
- Determination of Mebudipine in Human Plasma by Liquid Chromatography-tandem Mass Spectrometry.Iranian journal of pharmaceutical research : IJPR · 2015Article
- Effect of T-type calcium channel blockers on spiral ganglion neurons of aged C57BL/6J mice.International journal of clinical and experimental medicine · 2015Article
- Taurine supplementation reduces oxidative stress and protects the liver in an iron-overload murine model.Molecular medicine reports · 2014Article
- Edaravone promotes functional recovery after mechanical peripheral nerve injury.Neural regeneration research · 2014Article
- Effects of ischemia and omeprazole preconditioning on functional recovery of isolated rat heart.Revista brasileira de cirurgia cardiovascular : orgao oficial da Sociedade Brasileira de Cirurgia CardiovascularArticle
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5 authors at 1 institution in 1 country.
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Abstract
backgroundMyocardial infarction (MI) is the acute condition of necrosis in myocardium which occurs as a result of imbalance between coronary blood supply and myocardial demand. The resultant oxidative stress excess leads to worsen the condition. The aim of this study was to investigate the effect of mebudipine, a new dihydropyridine calcium channel blocker, on lipid peroxidation and antioxidant enzymes in myocardial ischemia-reperfusion injury. MATERIALS AND
methodsMale Wistar rats (250-300 g) were randomly divided to Control-ischemic, mebudipine-ischemic and vehicle (ethanol-ischemic) groups. The hearts of anaesthetized rats were removed and mounted on Langendorff apparatus and perfused by Krebs-Henseleit solution under constant pressure of 75 mmHg at 37°C. Ischemic groups were received 30 min global ischemia and 120 min reperfusion and the mebudipine and vehicle groups received mebudipine (0.1 nM) or ethanol (0.01%)-enriched solution 25 min before global ischemia. Malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase levels of heart tissue samples were determined by commercial specific Kits.
resultsMebudipine significantly reduced the MDA level (2.3 ± 0.07 nmol/mg protein) as the biochemical indicator of oxidative damage and lipid peroxidation product as compared with those of vehicle (4.6 ± 0.01 nmol/mg protein) and control groups (4.8 ± 0.09 nmol/mg protein). Furthermore, antioxidant enzymes SOD (0.1 ± 0.006 in drug vs. 0.037 ± 0.009 U/mg Protein in control), GPX (16 ± 0.009 in drug vs. 0.068 ± 0.01 U/mg Protein in control) and catalase activities (0.075 ± 0.006 in drug vs. 0.028 ± 0.002 U/mg Protein in control), activities of myocardium were significantly increased by mebudipine (P < 0.01).
conclusionOur results showed that mebudipine may have antioxidant activity against myocardial ischemia-reperfusion injury since it decreased oxidative stress by enhancing the enzymatic antioxidant defense and inhibiting the lipid peroxidation. Thus, this drug can reduce the intensity of cardiac ischemic insults.
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23853633PMC3703167W1506169276What OpenQuestion holds
Registered trials
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