ArticlePLoS biology2013
NKT cell-TCR expression activates conventional T cells in vivo, but is largely dispensable for mature NKT cell biology.
Article in PLoS biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
- A common transcriptomic program acquired in the thymus defines tissue residency of MAIT and NKT subsets.The Journal of experimental medicine · 2019Trial
- CD1a and Lipids as Mediators of T Cell Activation in the Skin.The Journal of investigative dermatology · 2025Review
- Article
- Role of MR1-driven signals and amphiregulin on the recruitment and repair function of MAIT cells during skin wound healing.Immunity · 2023Article
- Combined extract of heated TC1, a heat-killed preparation of Lactobacillus casei and alpha-galactosyl ceramide in a mouse model of cervical cancer.Infectious agents and cancer · 2022Article
- γδ T, NKT, and MAIT Cells During Evolution: Redundancy or Specialized Functions?Journal of immunology (Baltimore, Md. : 1950) · 2022Review
- In vivo availability of the cytokine IL-7 constrains the survival and homeostasis of peripheral iNKT cells.Cell reports · 2022Article
- Allotransplantation Is Associated With Exacerbation of CD8 T-Cell Senescence: The Particular Place of the Innate CD8 T-Cell Component.Frontiers in immunology · 2021Article
- Nur77 controls tolerance induction, terminal differentiation, and effector functions in semi-invariant natural killer T cells.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- Coincident airway exposure to low-potency allergen and cytomegalovirus sensitizes for allergic airway disease by viral activation of migratory dendritic cells.PLoS pathogens · 2019Article
- Transcriptional and epigenetic regulation of innate-like T lymphocyte development.Current opinion in immunology · 2018Review
- Differing roles of CD1d2 and CD1d1 proteins in type I natural killer T cell development and function.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The Impact of Invariant NKT Cells in Sterile Inflammation: The Possible Contribution of the Alarmin/Cytokine IL-33.Frontiers in immunology · 2018Review
- Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity.The Journal of experimental medicine · 2017Article
- T Cells Going Innate.Trends in immunology · 2016Review
- CD1d-restricted peripheral T cell lymphoma in mice and humans.The Journal of experimental medicine · 2016Article
- CDR3β sequence motifs regulate autoreactivity of human invariant NKT cell receptors.Journal of autoimmunity · 2016Article
- Pak2 Controls Acquisition of NKT Cell Fate by Regulating Expression of the Transcription Factors PLZF and Egr2.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Immune-based Therapy Clinical Trials in Hepatocellular Carcinoma.Journal of clinical & cellular immunology · 2015Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural killer T (NKT) cell development depends on recognition of self-glycolipids via their semi-invariant Vα14i-TCR. However, to what extent TCR-mediated signals determine identity and function of mature NKT cells remains incompletely understood. To address this issue, we developed a mouse strain allowing conditional Vα14i-TCR expression from within the endogenous Tcrα locus. We demonstrate that naïve T cells are activated upon replacement of their endogenous TCR repertoire with Vα14i-restricted TCRs, but they do not differentiate into NKT cells. On the other hand, induced TCR ablation on mature NKT cells did not affect their lineage identity, homeostasis, or innate rapid cytokine secretion abilities. We therefore propose that peripheral NKT cells become unresponsive to and thus are independent of their autoreactive TCR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.