ArticleJournal of computational physics2013
Temporal Multiscale Approach for Nanocarrier Motion with Simultaneous Adhesion and Hydrodynamic Interactions in Targeted Drug Delivery.
Article in Journal of computational physics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The trial behind it
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Who cites it
12 citing papers in PubMed.
- A parallel fluid-solid coupling model usingJournal of computational science · 2018Article
- Computational Models for Nanoscale Fluid Dynamics and Transport Inspired by Nonequilibrium Thermodynamics.Journal of heat transfer · 2017Article
- Nanoparticle transport and delivery in a heterogeneous pulmonary vasculature.Journal of biomechanics · 2017Article
- Characterization of Nanoparticle Dispersion in Red Blood Cell Suspension by the Lattice Boltzmann-Immersed Boundary Method.Nanomaterials (Basel, Switzerland) · 2016Article
- Nanoparticle stochastic motion in the inertial regime and hydrodynamic interactions close to a cylindrical wall.Physical review fluids · 2016Article
- Composite generalized Langevin equation for Brownian motion in different hydrodynamic and adhesion regimes.Physical review. E, Statistical, nonlinear, and soft matter physics · 2015Article
- Nanocarrier Hydrodynamics and Binding in Targeted Drug Delivery: Challenges in Numerical Modeling and Experimental Validation.Journal of nanotechnology in engineering and medicine · 2013Review
- A hybrid approach for the simulation of a nearly neutrally buoyant nanoparticle thermal motion in an incompressible Newtonian fluid medium.Journal of heat transfer · 2013Article
- Nanocarrier-Cell Surface Adhesive and Hydrodynamic Interactions: Ligand-Receptor Bond Sensitivity Study.Journal of nanotechnology in engineering and medicine · 2012Article
- Using 3-D dense packing models to predict surface tension change due to protein adsorption.International journal of transport phenomena · 2011Article
- Finite-sized gas bubble motion in a blood vessel: non-Newtonian effects.Physical review. E, Statistical, nonlinear, and soft matter physics · 2008Article
- Numerical study of wall effects on buoyant gas-bubble rise in a liquid-filled finite cylinder.Physical review. E, Statistical, nonlinear, and soft matter physics · 2007Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
We present a fluctuating hydrodynamics approach and a hybrid approach combining fluctuating hydrodynamics with generalized Langevin dynamics to resolve the motion of a nanocarrier when subject to both hydrodynamic interactions and adhesive interactions. Specifically, using these approaches, we compute equilibrium probability distributions at constant temperature as well as velocity autocorrelation functions of the nanocarrier subject to thermal motion in a quiescent Newtonian fluid medium, when tethered by a harmonic spring force mimicking a tether due to a single receptor-ligand bond. We demonstrate that the thermal equipartition of translation, rotation, and spring degrees of freedom are preserved by our formalism while simultaneously resolving the nature of the hydrodynamic correlations. Additionally, we evaluate the potential of mean force (or free energy density) along a specified reaction coordinate to faciltate extensive conformational sampling of the nanocarrier motion. We show that our results are in excellent agreement with analytical results and Monte Carlo simulations, thereby validating our methodologies. The frameworks we have presented provide a comprehensive platform for temporal multiscale modeling of hydrodynamic and microscopic interactions mediating nanocarrier motion and adhesion in vascular targeted drug delivery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.