ArticleDevelopmental neurobiology2014
RNA-binding protein Vg1RBP regulates terminal arbor formation but not long-range axon navigation in the developing visual system.
Article in Developmental neurobiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Long-range chemical signalling in vivo is regulated by mechanical signals.Nature materials · 2026Article
- RNA binding protein IGF2BP2 expression is induced by stress in the heart and mediates dilated cardiomyopathy.Communications biology · 2023Article
- The Fine Art of Writing a Message: RNA Metabolism in the Shaping and Remodeling of the Nervous System.Frontiers in molecular neuroscience · 2021Review
- Local Translation Across Neural Development: A Focus on Radial Glial Cells, Axons, and Synaptogenesis.Frontiers in molecular neuroscience · 2021Review
- Molecular mechanisms behind mRNA localization in axons.Open biology · 2020Review
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- mRNP assembly, axonal transport, and local translation in neurodegenerative diseases.Brain research · 2018Review
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- Sonic Hedgehog Guides Axons via Zipcode Binding Protein 1-Mediated Local Translation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Mechanosensing is critical for axon growth in the developing brain.Nature neuroscience · 2016Article
- RNA-binding proteins in eye development and disease: implication of conserved RNA granule components.Wiley interdisciplinary reviews. RNA · 2016Review
- Quantitative Analysis of Axonal Branch Dynamics in the Developing Nervous System.PLoS computational biology · 2016Article
- Drosophila Imp iCLIP identifies an RNA assemblage coordinating F-actin formation.Genome biology · 2015Article
- The RNA Binding Protein Igf2bp1 Is Required for Zebrafish RGC Axon Outgrowth In Vivo.PloS one · 2015Article
- Involvement of Rho-family GTPases in axon branching.Small GTPases · 2014Review
- Mitochondria coordinate sites of axon branching through localized intra-axonal protein synthesis.Cell reports · 2013Article
- The central dogma decentralized: new perspectives on RNA function and local translation in neurons.Neuron · 2013Review
- Cell biology in neuroscience: RNA-based mechanisms underlying axon guidance.The Journal of cell biology · 2013Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Local synthesis of β-actin is required for attractive turning responses to guidance cues of growth cones in vitro but its functional role in axon guidance in vivo is poorly understood. The transport and translation of β-actin mRNA is regulated by the RNA-binding protein, Vg1RBP (zipcode-binding protein-1). To examine whether Vg1RBP plays a role in axon navigation in vivo, we disrupted Vg1RBP function in embryonic Xenopus laevis retinal ganglion cells by expressing a dominant-negative Vg1RBP and by antisense morpholino knockdown. We found that attractive turning to a netrin-1 gradient in vitro was abolished in Vg1RBP-deficient axons but, surprisingly, the long-range navigation from the retina to the optic tectum was unaffected. Within the tectum, however, the branching and complexity of axon terminals were significantly reduced. High-resolution time-lapse imaging of axon terminals in vivo revealed that Vg1RBP-GFP-positive granules accumulate locally in the axon shaft immediately preceding the emergence a filopodial-like protrusion. Comparative analysis of branch dynamics showed that Vg1RBP-deficient axons extend far fewer filopodial-like protrusions than control axons and indicate that Vg1RBP promotes filopodial formation, an essential step in branch initiation. Our findings show that Vg1RBP is required for terminal arborization but not long-range axon navigation and suggest that Vg1RBP-regulated mRNA translation promotes synaptic complexity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.