ArticleThe Journal of biological chemistry2013
Interaction of E2F7 transcription factor with E2F1 and C-terminal-binding protein (CtBP) provides a mechanism for E2F7-dependent transcription repression.
Article in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- E2F1 K117 methylation by SETD6 disrupts BRD4-E2F1 binding and modulates E2F1 chromatin binding and gene regulation in prostate cancer cells.Nucleic acids research · 2026Article
- The transcriptional repressor Ctbp2 as a metabolite sensor regulating cardiomyocytes proliferation and heart regeneration.Molecular medicine (Cambridge, Mass.) · 2025Article
- Review
- Atlas of regulated target genes of transcription factors (ART-TF) in human ES cells.BMC bioinformatics · 2022Article
- Article
- Differential Expression of Mitosis and Cell Cycle Regulatory Genes during Recovery from an Acute Respiratory Virus Infection.Pathogens (Basel, Switzerland) · 2021Article
- Efficient induction and sustenance of pluripotent stem cells from bovine somatic cells.Biology open · 2021Article
- Identification of E2F transcription factor 7 as a novel potential biomarker for oral squamous cell carcinoma.Head & face medicine · 2021Article
- An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer's disease.Nature genetics · 2020Article
- Cell cycle oscillators underlying orderly proteolysis of E2F8.Molecular biology of the cell · 2020Article
- Circular RNA PRKCI promotes glioma cell progression by inhibiting microRNA-545.Cell death & disease · 2019Article
- E2F1 and E2F7 differentially regulate KPNA2 to promote the development of gallbladder cancer.Oncogene · 2019Article
- Zinc finger proteins orchestrate active gene silencing during embryonic stem cell differentiation.Nucleic acids research · 2018Article
- Comprehensive molecular biomarker identification in breast cancer brain metastases.Journal of translational medicine · 2017Article
- Pattern-based Search of Epigenomic Data Using GeNemo.Journal of visualized experiments : JoVE · 2017Article
- Information-dependent enrichment analysis reveals time-dependent transcriptional regulation of the estrogen pathway of toxicity.Archives of toxicology · 2017Article
- Identification of a Low-Frequency Missense Variant in E2F Transcription Factor 7 Associated with Colorectal Cancer Risk In A Chinese PopulationAsian Pacific journal of cancer prevention : APJCP · 2017Article
- CDKN2A-independent role of BMI1 in promoting growth and survival of Ph+ acute lymphoblastic leukemia.Leukemia · 2016Article
- Genome-wide analysis reveals NRP1 as a direct HIF1α-E2F7 target in the regulation of motorneuron guidance in vivo.Nucleic acids research · 2016Article
- Structural insights into the DNA-binding specificity of E2F family transcription factors.Nature communications · 2015Article
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5 authors at 2 institutions in 1 country.
Funding
Abstract
Previous work has identified distinct functions for E2F proteins during a cellular proliferative response including a role for E2F1-3 in the activation of transcription at G1/S and a role for E2F4-8 in repressing the same group of E2F1-3 target genes as cells progress through S phase. We now find that E2F7 and E2F8, which are induced by E2F1-3 at G1/S, can form a heterodimer with E2F1 through interactions involving the DNA-binding domains of the two proteins. In vitro DNA interaction assays demonstrate the formation of an E2F1-E2F7 complex, as well as an E2F7-E2F7 complex on adjacent E2F-binding sites. We also show that E2F7 recruits the co-repressor C-terminal-binding protein (CtBP) and that CtBP2 is essential for E2F7 to repress E2F1 transcription. Taken together, these findings suggest a mechanism for the repression of transcription by E2F7.
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