ArticlePediatric pulmonology2014
High frequency oscillation and airway pressure release ventilation in pediatric respiratory failure.
Article in Pediatric pulmonology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Recommendations for mechanical ventilation of critically ill children from the Paediatric Mechanical Ventilation Consensus Conference (PEMVECC).Intensive care medicine · 2017Guideline
- High-frequency oscillatory ventilation for respiratory failure after congenital heart surgery: a retrospective analysis.Anaesthesiology intensive therapy · 2023Article
- Does airway pressure release ventilation offer new hope for treating acute respiratory distress syndrome?Journal of intensive medicine · 2022Review
- Development of a Standardized Clinical Assessment and Management Plan for Pediatric Acute Respiratory Distress Syndrome.Journal of pediatric intensive care · 2022Article
- Comparison of Airway Pressure Release Ventilation to High-Frequency Oscillatory Ventilation in Neonates with Refractory Respiratory Failure.International journal of pediatrics · 2022Article
- A narrative review of advanced ventilator modes in the pediatric intensive care unit.Translational pediatrics · 2021Review
- Mechanical Ventilation in Pediatric and Neonatal Patients.Frontiers in physiology · 2021Review
- Airway Pressure Release Ventilation as a Rescue Therapy in Pediatric Acute Respiratory Distress Syndrome (pARDS): Goodwill or Devil?Indian journal of pediatrics · 2020Article
- Airway Pressure Release Ventilation as a Rescue Therapy in Pediatric Acute Respiratory Distress Syndrome.Indian journal of pediatrics · 2020Observational
- Outcomes of Severe PARDS on High-Frequency Oscillatory Ventilation - A Single Centre Experience.Indian journal of pediatrics · 2020Article
- High-frequency oscillatory ventilation in a tertiary paediatric intensive care unit in an academic hospital in Johannesburg, South Africa.The Southern African journal of critical care : the official journal of the Critical Care Society · 2019Article
- High-Frequency Oscillatory Ventilation Use and Severe Pediatric ARDS in the Pediatric Hematopoietic Cell Transplant Recipient.Respiratory care · 2018Article
- The 30-year evolution of airway pressure release ventilation (APRV).Intensive care medicine experimental · 2016Review
- High-frequency oscillatory ventilation is an effective treatment for severe pediatric acute respiratory distress syndrome with refractory hypoxemia.Therapeutics and clinical risk management · 2016Article
- Factors associated with interhospital transfer of children with respiratory failure from level II to level I pediatric intensive care units.Journal of critical care · 2015Article
- Corticosteroid exposure in pediatric acute respiratory distress syndrome.Intensive care medicine · 2015Observational
- Factors Associated with Survival during High-Frequency Oscillatory Ventilation in Children.Journal of pediatric intensive care · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAirway pressure release ventilation (APRV) and high frequency oscillatory ventilation (HFOV) are frequently used in acute lung injury (ALI) refractory to conventional ventilation. Our aim was to describe our experience with APRV and HFOV in refractory pediatric ALI, and to identify factors associated with survival.
methodsWe analyzed 104 patients with hypoxemia refractory to conventional ventilation transitioned to either APRV or HFOV. Demographics, oxygenation index (OI), and PaO2 /FiO2 (PF ratio) were recorded before transition to either mode of nonconventional ventilation (NCV) and for every 12 hr after transition.
resultsRelative to APRV, patients on HFOV were younger and had more significant lung disease evidenced by higher OI (28.5 [18.6, 36.2] vs. 21.0 [15.5, 30.0], P = 0.008), lower PF ratios (73 [59,94] vs. 99 [76,131], P = 0.002), and more frequent use of inhaled nitric oxide. In univariate analysis, HFOV was associated with more frequent neuromuscular blockade. Forty-one of 104 patients died on NCV (39.4%). Survivors demonstrated improvement in OI 24 hr after transition to NCV, whereas non-survivors did not (12.9 [8.9, 20.9] vs. 28.1 [17.6, 37.1], P < 0.001). After controlling for immunocompromised status, number of vasopressors, and OI before transition, mode of NCV was not associated with mortality.
conclusionsIn a heterogeneous PICU population with hypoxemia refractory to conventional ventilation transitioned to NCV, improvement in oxygenation at 24 hr was associated with survival. Immunocompromised status, number of vasopressor infusions, and the OI before transition to NCV were independently associated with survival.
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