ArticleJournal of clinical laboratory analysis2013
Reduced plasma citrulline levels in low birth weight infants with necrotizing enterocolitis.
Article in Journal of clinical laboratory analysis, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- L-Citrulline in Neonates: From Bench to Bed Side.Children (Basel, Switzerland) · 2024Review
- Necrotizing enterocolitis: current understanding of the prevention and management.Pediatric surgery international · 2024Review
- L-citrulline attenuates lipopolysaccharide-induced inflammatory lung injury in neonatal rats.Pediatric research · 2023Article
- Fecal amine metabolite analysis before onset of severe necrotizing enterocolitis in preterm infants: a prospective case-control study.Scientific reports · 2022Article
- Use of a Liquid Supplement Containing 2 Human Milk Oligosaccharides: The First Double-Blind, Randomized, Controlled Trial in Pre-term Infants.Frontiers in pediatrics · 2022Article
- Citrulline, Biomarker of Enterocyte Functional Mass and Dietary Supplement. Metabolism, Transport, and Current Evidence for Clinical Use.Nutrients · 2021Review
- Newborn metabolic vulnerability profile identifies preterm infants at risk for mortality and morbidity.Pediatric research · 2021Article
- Plasma Amino Acid Concentrations at Birth and Patent Ductus Arteriosus in Very and Extremely Preterm Infants.Frontiers in pediatrics · 2021Article
- [Application of metabolomics in neonatal clinical practice].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019Review
- Use of serum citrulline concentrations from routine newborn screen as a biomarker for necrotizing enterocolitis.Pediatric surgery international · 2019Article
- Citrulline as a marker of intestinal function and absorption in clinical settings: A systematic review and meta-analysis.United European gastroenterology journal · 2018Review
- Correlation between plasma levels of arginine and citrulline in preterm and full-term neonates: Therapeutical implications.Journal of clinical laboratory analysis · 2017Article
- The Microbiome and Biomarkers for Necrotizing Enterocolitis: Are We Any Closer to Prediction?The Journal of pediatrics · 2017Review
- The Role of Immunonutrients in the Prevention of Necrotizing Enterocolitis in Preterm Very Low Birth Weight Infants.Nutrients · 2015Review
- Arginine depletion increases susceptibility to serious infections in preterm newborns.Pediatric research · 2015Review
- High Protein Diet and Huntington's Disease.PloS one · 2015Article
- Plasma levels of dimethylarginines in preterm very low birth weight neonates: its relation with perinatal factors and short-term outcome.International journal of molecular sciences · 2014Article
- Effects of early enteral micro-feeding on neonatal serum Vitamin D levels.Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCitrulline, a nonprotein amino acid, is an intermediate of the urea cycle and synthesized in small intestine. Lower plasma citrulline levels were associated with reduced function of enterocytes. Necrotizing enterocolitis (NEC) causes high morbidity and mortality, and leads impaired intestinal functions.
methodsPlasma citrulline levels of neonates with a gestational age <32 weeks and ≤1,500 gm who developed NEC stage II/III were measured by high-performance liquid chromatography.
resultsWe enrolled 36 preterm infants including 20 with NEC and 16 controls. Median citrulline levels of NEC and control groups were 8.6 and 20.18 μmol/l (P < 0.05), and cut off level of citrulline was 13.15 μmol/l with a sensitivity of 80% and a specificity of 82%. Median arginine levels of NEC and control groups were 22.02 and 39.89 μmol/l (P < 0.05), and cut off level of arginine was 28.52 μmol/l with a sensitivity of 70% and a specificity of 75%. Blood sampling day, gender, parenteral, and enteral nutrition did not affect the amino acid levels.
conclusionWe found lower plasma citrulline and arginine levels in preterm infants with NEC. Further studies are needed to determine most appropriate levels to predict recovery and prognosis of NEC, and treatment options with these amino acids in preterm infants.
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