ReviewCellular and molecular life sciences : CMLS2013
The unique features of follicular T cell subsets.
Review in Cellular and molecular life sciences : CMLS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Interleukin-21 responses in patients with chronic hepatitis B.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2015Trial
- Integrative Transcriptomic and Network Pharmacology Analysis Reveals Key Targets and Mechanisms ofPharmaceuticals (Basel, Switzerland) · 2025Article
- Surra-affected dromedary camels show reduced numbers of blood B-cells and in vitro evidence of Trypanosoma-induced B cell death.Tropical animal health and production · 2024Article
- Advances in the Immunology of the Host-Parasite Interactions in African Trypanosomosis, including Single-Cell Transcriptomics.Pathogens (Basel, Switzerland) · 2024Review
- Decreased natural killer T-like cells correlated to disease activity in systemic lupus erythematosus.Clinical rheumatology · 2023Article
- Neuropilin-1 (NRP1) expression distinguishes self-reactive helper T cells in systemic autoimmune disease.EMBO molecular medicine · 2022Article
- From Signaling Pathways to Distinct Immune Responses: Key Factors for Establishing or CombatingPathogens (Basel, Switzerland) · 2020Review
- Host Immune Responses and Immune Evasion Strategies in African Trypanosomiasis.Frontiers in immunology · 2019Review
- Th1high in tumor microenvironment is an indicator of poor prognosis for patients with NSCLC.Oncotarget · 2017Article
- IFN-γ receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity.The Journal of experimental medicine · 2016Article
- Circulating memory T follicular helper subsets, Tfh2 and Tfh17, participate in the pathogenesis of Guillain-Barré syndrome.Scientific reports · 2016Article
- IL-4-secreting secondary T follicular helper (Tfh) cells arise from memory T cells, not persisting Tfh cells, through a B cell-dependent mechanism.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- The B cell adaptor molecule Bam32 is critically important for optimal antibody response and resistance to Trypanosoma congolense infection in mice.PLoS neglected tropical diseases · 2015Article
- ICOS maintains the T follicular helper cell phenotype by down-regulating Krüppel-like factor 2.The Journal of experimental medicine · 2015Article
- Circulating CCR7+ICOS+ Memory T Follicular Helper Cells in Patients with Multiple Sclerosis.PloS one · 2015Article
- Impaired function of CD4+ T follicular helper (Tfh) cells associated with hepatocellular carcinoma progression.PloS one · 2015Article
- Immunoregulation of NKT Cells in Systemic Lupus Erythematosus.Journal of immunology research · 2015Review
- Follicular Helper CD4+ T Cells in Human Neuroautoimmune Diseases and Their Animal Models.Mediators of inflammation · 2015Review
- Article
- Transcriptional and epigenetic regulation of T-helper lineage specification.Immunological reviews · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The germinal center (GC) reaction is critical for humoral immunity, but also contributes adversely to a variety of autoimmune diseases. While the major protective function of GCs is mediated by plasma cells and memory B cells, follicular helper T (TFH) cells represent a specialized T cell subset that provides essential help to the antigen-specific B cells in the form of membrane-bound ligands and secreted factors such as IL-21. Recent studies have revealed that TFH cells are capable of considerable functional diversity as well as possessing the ability to form memory cells. The molecular basis of this plasticity and heterogeneity is only now emerging. It has also become apparent that several other populations of follicular T cells exist, including natural killer T cells and regulatory T cells. In this review we will discuss the function of follicular T cells and interaction of these populations within the GC response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.