ArticleGenetics2013
Viability, longevity, and egg production of Drosophila melanogaster are regulated by the miR-282 microRNA.
Article in Genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Small RNA Sequencing Reveals Dynamic Expression Profiles and Regulatory Network of miRNAs During Testis Development of Macrobrachium rosenbergii.Marine biotechnology (New York, N.Y.) · 2026Article
- Sex-Biased Transcription Expression of Vitellogenins Reveals Fusion Gene and MicroRNA Regulation in the Sea Louse Caligus rogercresseyi.Marine biotechnology (New York, N.Y.) · 2024Article
- MicroRNAs in Age-Related Proteostasis and Stress Responses.Non-coding RNA · 2023Review
- Review
- Sexually dimorphic microRNA miR-190 regulates lifespan in maleRNA biology · 2022Article
- The developmentally dynamic microRNA transcriptome ofBioinformatics advances · 2022Article
- A mini-screen to identify the role of microRNAs in the Drosophila Insulin-Producing cells regulating lifespan.microPublication biology · 2022Article
- MicroRNAs as modulators of longevity and the aging process.Human genetics · 2020Review
- Genome-Wide Analysis of MicroRNAs in Relation to Pupariation in Oriental Fruit Fly.Frontiers in physiology · 2019Article
- Regulators of Long-Term Memory Revealed by Mushroom Body-Specific Gene Expression Profiling inGenetics · 2018Article
- Identification of Differentially Expressed miRNAs in Colorado Potato Beetles (Leptinotarsa decemlineata (Say)) Exposed to Imidacloprid.International journal of molecular sciences · 2017Article
- MicroRNAs are differentially abundant during Aedes albopictus diapause maintenance but not diapause induction.Insect molecular biology · 2017Article
- Transgenerational programming of longevity through E(z)-mediated histone H3K27 trimethylation inAging · 2016Article
- Article
- Genome-Wide Analysis of Differentially Expressed microRNA in Bombyx mori Infected with Nucleopolyhedrosis Virus.PloS one · 2016Article
- MicroRNAs in the oriental fruit fly, Bactrocera dorsalis: extending Drosophilid miRNA conservation to the Tephritidae.BMC genomics · 2015Article
- Regulation of physiological processes by microRNAs in insects.Current opinion in insect science · 2015Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The first microRNAs were discovered some 20 years ago, but only a small fraction of the microRNA-encoding genes have been described in detail yet. Here we report the molecular analysis of a computationally predicted Drosophila melanogaster microRNA gene, mir-282. We show that the mir-282 gene is the source of a 4.9-kb-long primary transcript with a 5' cap and a 3'-poly(A) sequence and a mature microRNA of ∼25 bp. Our data strongly suggest the existence of an independent mir-282 gene conserved in holometabolic insects. We give evidence that the mir-282 locus encodes a functional transcript that influences viability, longevity, and egg production in Drosophila. We identify the nervous system-specific adenylate cyclase (rutabaga) as a target of miR-282 and assume that one of the main functions of mir-282 is the regulation of adenylate cyclase activity in the nervous system during metamorphosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.