ArticleGenetics2013
Correlation between mutation rate and genome size in riboviruses: mutation rate of bacteriophage Qβ.
Article in Genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Concepts of RNA virus evolution for the design of better antiviral countermeasures.Nature reviews. Microbiology · 2026Review
- Navigating the Fitness Landscape: Host Density, Epistasis, and Clonal Interference Drive Divergent Evolutionary Pathways in Phage Qβ.International journal of molecular sciences · 2025Article
- Metagenomic Investigation of Intestinal Microbiota of Insectivorous Synanthropic Bats: Densoviruses, Antibiotic Resistance Genes, and Functional Profiling of Gut Microbial Communities.International journal of molecular sciences · 2025Article
- Advancing RNA phage biology through meta-omics.Nucleic acids research · 2025Review
- Impact of simulated microgravity in short-term evolution of an RNA bacteriophage.Frontiers in microbiology · 2025Article
- In silico prediction of pathogen's pandemic potential using the viral trait assessment for pandemics (ViTAP) model.PNAS nexus · 2024Article
- Fidelity Characterization of Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus and NADC30-like Strain.Viruses · 2024Article
- Evolutionary Adaptation of an RNA Bacteriophage to Repeated Freezing and Thawing Cycles.International journal of molecular sciences · 2024Article
- Quasispecies Nature of RNA Viruses: Lessons from the Past.Vaccines · 2023Review
- Exhaustive mutational analysis of severe acute respiratory syndrome coronavirus 2 ORF3a: An essential component in the pathogen's infectivity cycle.Protein science : a publication of the Protein Society · 2023Article
- Mutation rate, selection, and epistasis inferred from RNA virus haplotypes via neural posterior estimation.Virus evolution · 2023Article
- Standing Genetic Diversity and Transmission Bottleneck Size Drive Adaptation in Bacteriophage Qβ.International journal of molecular sciences · 2022Article
- Inferring the distribution of fitness effects in patient-sampled and experimental virus populations: two case studies.Heredity · 2022Article
- Distinct Retrotransposon Evolution Profile in the Genome of Rabbit (Oryctolagus cuniculus).Genome biology and evolution · 2021Article
- Intra-Population Competition during Adaptation to Increased Temperature in an RNA Bacteriophage.International journal of molecular sciences · 2021Article
- SARS-CoV-2 biology and variants: anticipation of viral evolution and what needs to be done.Environmental microbiology · 2021Article
- cDNA-Derived RNA Phage Assembly Reveals Critical Residues in the Maturation Protein of the Pseudomonas aeruginosa Leviphage PP7.Journal of virology · 2021Article
- New Perspectives on Antimicrobial Agents: Remdesivir Treatment for COVID-19.Antimicrobial agents and chemotherapy · 2020Review
- Compounds with Therapeutic Potential against Novel Respiratory 2019 Coronavirus.Antimicrobial agents and chemotherapy · 2020Review
- The Role of Temperature in Shaping Mosquito-Borne Viruses Transmission.Frontiers in microbiology · 2020Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Genome sizes and mutation rates covary across all domains of life. In unicellular organisms and DNA viruses, they show an inverse relationship known as Drake's rule. However, it is still unclear whether a similar relationship exists between genome sizes and mutation rates in RNA genomes. Coronaviruses, the RNA viruses with the largest genomes (∼30 kb), encode a proofreading 3' exonuclease that allows them to increase replication fidelity. However, it is unknown whether, conversely, the RNA viruses with the smallest genomes tend to show particularly high mutation rates. To test this, we measured the mutation rate of bacteriophage Qβ, a 4.2-kb levivirus. Amber reversion-based Luria-Delbrück fluctuation tests combined with mutant sequencing gave an estimate of 1.4 × 10(-4) substitutions per nucleotide per round of copying, the highest mutation rate reported for any virus using this method. This estimate was confirmed using a direct plaque sequencing approach and after reanalysis of previously published estimates for this phage. Comparison with other riboviruses (all RNA viruses except retroviruses) provided statistical support for a negative correlation between mutation rates and genome sizes. We suggest that the mutation rates of RNA viruses might be optimized for maximal adaptability and that the value of this optimum may in turn depend inversely on genome size.
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