ArticleNature neuroscience2013
Bidirectional NMDA receptor plasticity controls CA3 output and heterosynaptic metaplasticity.
Article in Nature neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 60 citations in OpenAlex.
- Heterosynaptic NMDA receptor plasticity in hippocampal dentate granule cells.Frontiers in synaptic neuroscience · 2026Article
- Selective inhibition in CA3: A mechanism for stable pattern completion through heterosynaptic plasticity.PLoS computational biology · 2025Article
- Nucleus accumbens shell electrical lesion attenuates seizures and gliosis in chronic temporal lobe epilepsy rats.Epileptic disorders : international epilepsy journal with videotape · 2025Article
- Article
- Distinct Disruptions in CA1 and CA3 Place Cell Function in Alzheimer's Disease Mice.bioRxiv : the preprint server for biology · 2024Article
- NMDAR-mediated activation of pannexin1 channels contributes to the detonator properties of hippocampal mossy fiber synapses.iScience · 2024Article
- Terahertz Photons Improve Cognitive Functions in Posttraumatic Stress Disorder.Research (Washington, D.C.) · 2023Article
- Target cell-specific plasticity rules of NMDA receptor-mediated synaptic transmission in the hippocampus.Frontiers in cellular neuroscience · 2023Article
- A missense mutation inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Cell type-specific mechanisms of information transfer in data-driven biophysical models of hippocampal CA3 principal neurons.PLoS computational biology · 2022Article
- Role of NMDAR plasticity in a computational model of synaptic memory.Scientific reports · 2021Article
- Plasticity in the Hippocampus, Neurogenesis and Drugs of Abuse.Brain sciences · 2021Review
- Modulation of NMDA Receptors by G-protein-coupled receptors: Role in Synaptic Transmission, Plasticity and Beyond.Neuroscience · 2021Review
- Reduced GluN1 in mouse dentate gyrus is associated with CA3 hyperactivity and psychosis-like behaviors.Molecular psychiatry · 2020Article
- Rapid exchange of synaptic and extrasynaptic NMDA receptors in hippocampal CA1 neurons.Journal of neurophysiology · 2020Article
- Article
- Hippocampal Mossy Fibers Synapses in CA3 Pyramidal Cells Are Altered at an Early Stage in a Mouse Model of Alzheimer's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Intracellular ZnThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- High-resolution Immunoelectron Microscopy Techniques for Revealing Distinct Subcellular Type 1 Cannabinoid Receptor Domains in Brain.Bio-protocol · 2019Article
- A novel pyramidal cell type promotes sharp-wave synchronization in the hippocampus.Nature neuroscience · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
NMDA receptors (NMDARs) are classically known as coincidence detectors for the induction of long-term synaptic plasticity and have been implicated in hippocampal CA3 cell-dependent spatial memory functions that likely rely on dynamic cellular ensemble encoding of space. The unique functional properties of both NMDARs and mossy fiber projections to CA3 pyramidal cells place mossy fiber NMDARs in a prime position to influence CA3 ensemble dynamics. By mimicking presynaptic and postsynaptic activity patterns observed in vivo, we found a burst timing-dependent pattern of activity that triggered bidirectional long-term NMDAR plasticity at mossy fiber-CA3 synapses in rat hippocampal slices. This form of plasticity imparts bimodal control of mossy fiber-driven CA3 burst firing and spike temporal fidelity. Moreover, we found that mossy fiber NMDARs mediate heterosynaptic metaplasticity between mossy fiber and associational-commissural synapses. Thus, bidirectional NMDAR plasticity at mossy fiber-CA3 synapses could substantially contribute to the formation, storage and recall of CA3 cell assembly patterns.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.