ReviewInternational journal of molecular sciences2013
Regulatory non-coding RNAs in pluripotent stem cells.
Review in International journal of molecular sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- Identification of RNA-based cell-type markers for stem-cell manufacturing systems with a statistical scoring function.Gene reports · 2024Article
- Differential Expression of Non-Coding RNAs in Stem Cell Development and Therapeutics of Bone Disorders.Cells · 2023Review
- Highly sensitive and non-disruptive detection of residual undifferentiated cells by measuring miRNAs in culture supernatant.Scientific reports · 2022Article
- MicroRNA-367-3p induces apoptosis and suppresses migration of MCF-7 cells by downregulating the expression of human choline kinase α.Oncology letters · 2021Article
- The role of microRNAs in embryonic stem cell and induced pluripotent stem cell differentiation in male germ cells.Journal of cellular physiology · 2019Review
- Regenerative Cardiovascular Therapies: Stem Cells and Beyond.International journal of molecular sciences · 2019Review
- The microRNA and the perspectives of miR-302.Heliyon · 2019Review
- High resolution temporal transcriptomics of mouse embryoid body development reveals complex expression dynamics of coding and noncoding loci.Scientific reports · 2017Article
- STRIP2 Is Indispensable for the Onset of Embryonic Stem Cell Differentiation.Molecular therapy. Methods & clinical development · 2017Article
- Enhanced generation of iPSCs from older adult human cells by a synthetic five-factor self-replicative RNA.PloS one · 2017Article
- Multiple Roles of MYC in Integrating Regulatory Networks of Pluripotent Stem Cells.Frontiers in cell and developmental biology · 2017Review
- Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular disease.Nucleic acids research · 2016Article
- Infantile Hemangioma Originates From A Dysregulated But Not Fully Transformed Multipotent Stem Cell.Scientific reports · 2016Article
- Long Noncoding RNA Regulation of Pluripotency.Stem cells international · 2016Review
- Transcriptator: An Automated Computational Pipeline to Annotate Assembled Reads and Identify Non Coding RNA.PloS one · 2015Article
- Temporal and Spatial Expression Patterns of miR-302 and miR-367 During Early Embryonic Chick Development.International journal of stem cells · 2014Article
- Editorial on the Special Issue: Regulation by non-coding RNAs.International journal of molecular sciences · 2013Article
- Undifferentiated embryonic stem cells express ionotropic glutamate receptor mRNAs.Frontiers in cellular neuroscience · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
The most part of our genome encodes for RNA transcripts are never translated into proteins. These include families of RNA molecules with a regulatory function, which can be arbitrarily subdivided in short (less than 200 nucleotides) and long non-coding RNAs (ncRNAs). MicroRNAs, which act post-transcriptionally to repress the function of target mRNAs, belong to the first group. Included in the second group are multi-exonic and polyadenylated long ncRNAs (lncRNAs), localized either in the nucleus, where they can associate with chromatin remodeling complexes to regulate transcription, or in the cytoplasm, acting as post-transcriptional regulators. Pluripotent stem cells, such as embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs), represent useful systems for modeling normal development and human diseases, as well as promising tools for regenerative medicine. To fully explore their potential, however, a deep understanding of the molecular basis of stemness is crucial. In recent years, increasing evidence of the importance of regulation by ncRNAs in pluripotent cells is accumulating. In this review, we will discuss recent findings pointing to multiple roles played by regulatory ncRNAs in ESC and iPSCs, where they act in concert with signaling pathways, transcriptional regulatory circuitries and epigenetic factors to modulate the balance between pluripotency and differentiation.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.