ArticleJournal of visualized experiments : JoVE2013
Automated high-throughput behavioral analyses in zebrafish larvae.
Article in Journal of visualized experiments : JoVE, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Zebrafish swimming towards cures: a scalable NAM platform for drug discovery.Drug discovery today · 2026Review
- A high-throughput system for drug screening based on the movement analysis of zebrafish.Heliyon · 2024Article
- Article
- Behavioral effects of visual stimuli in adult zebrafish using a novel eight-tank imaging system.Frontiers in behavioral neuroscience · 2024Article
- Diving deep: zebrafish models in motor neuron degeneration research.Frontiers in neuroscience · 2024Review
- Orphan cytochrome P450 20a1 CRISPR/Cas9 mutants and neurobehavioral phenotypes in zebrafish.Scientific reports · 2021Article
- Article
- Behavior Individuality: A Focus onFrontiers in physiology · 2021Review
- A microfluidic device to study electrotaxis and dopaminergic system of zebrafish larvae.Biomicrofluidics · 2018Article
- Vitamin E deficiency during embryogenesis in zebrafish causes lasting metabolic and cognitive impairments despite refeeding adequate diets.Free radical biology & medicine · 2017Article
- Behavioral alterations of zebrafish larvae after early embryonic exposure to ketamine.Psychopharmacology · 2017Article
- Article
- An asymptomatic mutation complicating severe chemotherapy-induced peripheral neuropathy (CIPN): a case for personalised medicine and a zebrafish model of CIPN.NPJ genomic medicine · 2016Article
- Chlorpyrifos and malathion have opposite effects on behaviors and brain size that are not correlated to changes in AChE activity.Neurotoxicology · 2015Article
- Effects of embryonic cyclosporine exposures on brain development and behavior.Behavioural brain research · 2015Article
- Article
- Cluster analysis profiling of behaviors in zebrafish larvae treated with antidepressants and pesticides.Neurotoxicology and teratologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
We have created a novel high-throughput imaging system for the analysis of behavior in 7-day-old zebrafish larvae in multi-lane plates. This system measures spontaneous behaviors and the response to an aversive stimulus, which is shown to the larvae via a PowerPoint presentation. The recorded images are analyzed with an ImageJ macro, which automatically splits the color channels, subtracts the background, and applies a threshold to identify individual larvae placement in the lanes. We can then import the coordinates into an Excel sheet to quantify swim speed, preference for edge or side of the lane, resting behavior, thigmotaxis, distance between larvae, and avoidance behavior. Subtle changes in behavior are easily detected using our system, making it useful for behavioral analyses after exposure to environmental toxicants or pharmaceuticals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.