Evidence map›Paper›PMID 23851590›Full record

ArticleHuman vaccines & immunotherapeutics2013

A microarray method for identifying tumor antigens by screening a tumor cDNA expression library against cancer sera.

Kurt Whittemore, Kathryn Sykes

Abstract read
In one paragraph

Article in Human vaccines & immunotherapeutics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kurt WhittemoreCenter for Innovations in Medicine; The Biodesign Institute; Arizona State University; Tempe, AZ USA; Biological Design Program; Arizona State University; Tempe, AZ USA.
Kathryn SykesCenter for Innovations in Medicine; The Biodesign Institute; Arizona State University; Tempe, AZ USA; HealthTell, Inc.; Chandler, AZ USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The immune system responds to tumor cells. The challenge has been how to effectively use these responses to treat or protect against cancer. Toward the goal of developing a cancer vaccine, we are pursuing methodologies for the discovery and testing of useful antigens. We present an array-based approach for discovering these B cell antigens by directly screening for specific host-sera reactivity to lysates from tumor-derived cDNA expression libraries. Several cancer-specific antigens were identified, and these are currently being validated as potential candidates.

Indexed as

AnimalsAntigens, NeoplasmDrug DiscoveryFemaleGene LibraryHumansMice, Inbred BALB CMicroarray AnalysisAntigens, NeoplasmantibodycancercDNAimmunogenlibraryseratumorvaccine

Identifiers

PMID23851590
PMCPMC3906402

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.