Evidence map›Paper›PMID 23851495›Full record

ArticleOncogene2014

GSK3β controls epithelial-mesenchymal transition and tumor metastasis by CHIP-mediated degradation of Slug.

S-H Kao, W-L Wang, C-Y Chen, Y-L Chang, Y-Y Wu, Y-T Wang, S-P Wang, A I Nesvizhskii, Y-J Chen, T-M Hong and 1 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncogene, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 132 citations in OpenAlex.

  1. Article
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  4. Role of Ubiquitin-regulated EMT in Cancer Metastasis and Chemoresistance.International journal of biological sciences · 2025
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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

S-H KaoInstitute of Molecular Medicine, National Taiwan University, Taipei, Taiwan.
W-L WangInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
C-Y Chen1] Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan [2] Department of Nutrition and Health Sciences, Chang Gung University of Science and Technology, Taoyuan, Taiwan.
Y-L ChangDepartment of Pathology and Graduate Institute of Pathology, National Taiwan University, Taipei, Taiwan.
Y-Y Wu1] Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan [2] Graduate Institute of Clinical Medicine, National Cheng Kung University, Taipei, Taiwan.
Y-T Wang1] Chemical Biology and Molecular Biophysics Program, Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan [2] Institute of Chemistry, Academia Sinica, Taipei, Taiwan [3] Institute of Biochemical Sciences, College of Life Science, National Taiwan University, Taipei, Taiwan.
S-P Wang1] Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan [2] Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY, USA.
A I Nesvizhskii1] Department of Pathology, University of Michigan, Ann Arbor, MI, USA [2] Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Y-J Chen1] Chemical Biology and Molecular Biophysics Program, Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan [2] Institute of Chemistry, Academia Sinica, Taipei, Taiwan.
T-M HongGraduate Institute of Clinical Medicine, National Cheng Kung University, Taipei, Taiwan.
P-C Yang1] Institute of Molecular Medicine, National Taiwan University, Taipei, Taiwan [2] Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan [3] Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan [4] NTU Center of Genomic Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Institute of Biomedical Sciences, Academia Sinica · TWAcademia Sinica · TWNational Taiwan University · TWNational Cheng Kung University · TWUniversity of Michigan–Ann Arbor · US

Funding

COMPUTATIONAL TOOLS FOR MASS SPECTROMETRY-BASED INTERACTOME DATAR01GM094231 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 2010 to 2026
$5.4M
NIGMS NIH HHS R01 GM094231NIGMS NIH HHS R01-GM-094231
6 · The paper itself

Abstract

Glycogen synthase kinase 3 beta (GSK3β) is highly inactivated in epithelial cancers and is known to inhibit tumor migration and invasion. The zinc-finger-containing transcriptional repressor, Slug, represses E-cadherin transcription and enhances epithelial-mesenchymal transition (EMT). In this study, we find that the GSK3β-pSer9 level is associated with the expression of Slug in non-small cell lung cancer. GSK3β-mediated phosphorylation of Slug facilitates Slug protein turnover. Proteomic analysis reveals that the carboxyl terminus of Hsc70-interacting protein (CHIP) interacts with wild-type Slug (wtSlug). Knockdown of CHIP stabilizes the wtSlug protein and reduces Slug ubiquitylation and degradation. In contrast, nonphosphorylatable Slug-4SA is not degraded by CHIP. The accumulation of nondegradable Slug may further lead to the repression of E-cadherin expression and promote cancer cell migration, invasion and metastasis. Our findings provide evidence of a de novo GSK3β-CHIP-Slug pathway that may be involved in the progression of metastasis in lung cancer.

Indexed as

Epithelial-Mesenchymal TransitionAnimalsBlotting, WesternCadherinsCarcinoma, Non-Small-Cell LungCell MovementCell ProliferationCohort StudiesGene Expression Regulation, NeoplasticGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaHumansImmunoenzyme TechniquesImmunoprecipitationLung NeoplasmsMiceCadherinsGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaGSK3B protein, humanGsk3b protein, mouseRNA, MessengerSNAI1 protein, humanSnai2 protein, mouseSnail Family Transcription FactorsSTUB1 protein, humanTranscription FactorsUbiquitinUbiquitin-Protein Ligases

Identifiers

PMID23851495
PMCPMC4096338
OpenAlexW2081040180

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.