ArticleBioengineered
Putting bugs to the blush: metabolic engineering for phenylpropanoid-derived products in microorganisms.
Article in Bioengineered. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Engineering of Corynebacterium glutamicum for the synthesis of aromatic compounds.Applied microbiology and biotechnology · 2025Review
- Biotechnological Breakthroughs in Resveratrol Synthesis and Health Advancements.Current pharmaceutical biotechnology · 2025Review
- Synthetic Biology-Driven Microbial Production of Resveratrol: Advances and Perspectives.Frontiers in bioengineering and biotechnology · 2022Review
- CRISPR-mediated multigene integration enables Shikimate pathway refactoring for enhanced 2-phenylethanol biosynthesis in Kluyveromyces marxianus.Biotechnology for biofuels · 2021Article
- Anthocyanins and Anthocyanin-Derived Products in Yeast-Fermented Beverages.Antioxidants (Basel, Switzerland) · 2019Review
- Tailoring Corynebacterium glutamicum towards increased malonyl-CoA availability for efficient synthesis of the plant pentaketide noreugenin.Microbial cell factories · 2019Article
- Heterologous production of resveratrol in bacterial hosts: current status and perspectives.World journal of microbiology & biotechnology · 2018Review
- Production of Plant Secondary Metabolites: Examples, Tips and Suggestions for Biotechnologists.Genes · 2018Review
- Metabolic engineering of Escherichia coli for the synthesis of the plant polyphenol pinosylvin.Applied and environmental microbiology · 2015Article
- When plants produce not enough or at all: metabolic engineering of flavonoids in microbial hosts.Frontiers in plant science · 2015Review
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Authors and funding
2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Phenylpropanoids and phenylpropanoid-derived phenolic compounds such as flavonoids, anthocyanins, or stilbenes are secondary plant metabolites which serve as pigments and scent compounds or provide protection against environmental stress. Due to their antioxidant properties they also have been widely recognized for their benefit on human health. Traditionally, such compounds are extracted from their natural plant sources, but this approach is limited by low abundance and environmental, seasonal as well as regional variations in yield. Chemical synthesis is not a true alternative for the large scale production of more complex phenylpropanoid-derived substances since chemical synthesis becomes commercially unfeasible as the structural complexity of these plant natural products increases. In the last years, many biosynthetic pathways for plant natural products have been elucidated through the advancements in DNA sequencing technologies. In combination with new recombinant DNA technologies this technical progress opens the door toward the functional integration of full biosynthetic pathways for the synthesis of phenylpropanoids and phenylpropanoid-derived compounds in microorganisms. We believe that this approach has great potential to provide sufficient quantities of the desired plant natural product from cheap and renewable resources. This commentary highlights recent advances in the microbial production of phenylpropanoid-derived compounds with an emphasis on flavonoids and stilbenes.
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