ReviewRespiratory physiology & neurobiology2013
Serotonin gene variants are unlikely to play a significant role in the pathogenesis of the sudden infant death syndrome.
Review in Respiratory physiology & neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Update on the similarities between SADS, SIDS, and SUDEP: Three sides of the same pyramid?International journal of legal medicine · 2026Review
- Review
- Sudden infant death syndrome revisited: serotonin transporter gene, polymorphisms and promoter methylation.Pediatric research · 2022Article
- Development of a Risk Score to Predict Sudden Infant Death Syndrome.International journal of environmental research and public health · 2022Article
- Sudden Infant Death Syndrome: Beyond Risk Factors.Life (Basel, Switzerland) · 2021Review
- Genetic Factors Underlying Sudden Infant Death Syndrome.The application of clinical genetics · 2021Review
- Generations in Families Talking Safe Sleep (GIFTSS): Randomized Controlled Trial of a Safe Sleep Educational Intervention for Young Pregnant Women.Social science protocols · 2020Article
- Cardiac arrhythmia and neuroexcitability gene variants in resected brain tissue from patients with sudden unexpected death in epilepsy (SUDEP).NPJ genomic medicine · 2018Article
- SIDS-CDF Hypothesis Revisited: Cause vs. Contributing Factors.Frontiers in neurology · 2016Article
- Assigning cause for sudden unexpected infant death.Forensic science, medicine, and pathology · 2015Article
- Sodium/proton exchanger 3 (NHE3) and sudden infant death syndrome (SIDS).International journal of legal medicine · 2014Article
- The integrative role of the sigh in psychology, physiology, pathology, and neurobiology.Progress in brain research · 2014Review
- Clinical challenges to ventilatory control.Respiratory physiology & neurobiology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Sudden infant death syndrome (SIDS) is defined as the sudden and unexpected death of an infant less than 12 months of age that is related to a sleep period and remains unexplained after a complete autopsy, death scene investigation, and review of the clinical history. The cause of SIDS is unknown, but a major subset of SIDS is proposed to result from abnormalities in serotonin (5-HT) and related neurotransmitters in regions of the lower brainstem that result in failure of protective homeostatic responses to life-threatening challenges during sleep. Multiple studies have implicated gene variants that affect different elements of 5-HT neurotransmission in the pathogenesis of these abnormalities in SIDS. In this review I discuss the data from these studies together with some new data correlating genotype with brainstem 5-HT neurochemistry in the same SIDS cases and conclude that these gene variants are unlikely to play a major role in the pathogenesis of the medullary 5-HT abnormalities observed in SIDS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.