ArticleHuman molecular genetics2013
Different selective pressures shape the evolution of Toll-like receptors in human and African great ape populations.
Article in Human molecular genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 54 citations in OpenAlex.
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- Alterations in Signaling Pathways and Therapeutic Strategies of Traditional Chinese Medicine in Granulomatous Lobular Mastitis.Journal of inflammation research · 2025Review
- Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia.The Journal of experimental medicine · 2023Article
- Unlocking life-threatening COVID-19 through two types of inborn errors of type I IFNs.The Journal of clinical investigation · 2023Review
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- Common homozygosity for predicted loss-of-function variants reveals both redundant and advantageous effects of dispensable human genes.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Intrinsically disordered regions are abundant in simplexvirus proteomes and display signatures of positive selection.Virus evolution · 2020Article
- Evolutionary History of the Toll-Like Receptor Gene Family across Vertebrates.Genome biology and evolution · 2020Article
- Human genetics of infectious diseases: Unique insights into immunological redundancy.Seminars in immunology · 2018Review
- Article
- Rapidly Evolving Toll-3/4 Genes Encode Male-Specific Toll-Like Receptors in Drosophila.Molecular biology and evolution · 2017Article
- Characterization of the peripheral blood transcriptome and adaptive evolution of the MHC I and TLR gene families in the wolf (Canis lupus).BMC genomics · 2017Article
- Distinct selective forces and Neanderthal introgression shaped genetic diversity at genes involved in neurodevelopmental disorders.Scientific reports · 2017Article
- Evolution of toll-like receptors in the context of terrestrial ungulates and cetaceans diversification.BMC evolutionary biology · 2017Article
- Population genetics of mouse lemur vomeronasal receptors: current versus past selection and demographic inference.BMC evolutionary biology · 2017Article
- The evolutionary history of genes involved in spoken and written language: beyond FOXP2.Scientific reports · 2016Article
- Introgression of Neandertal- and Denisovan-like Haplotypes Contributes to Adaptive Variation in Human Toll-like Receptors.American journal of human genetics · 2016Article
- Models for preclinical studies in aging-related disorders: One is not for all.Translational medicine @ UniSa · 2015Article
- Interleukin-37 gene variants segregated anciently coexist during hominid evolution.European journal of human genetics : EJHG · 2015Article
- Causes and consequences of coagulation activation in sepsis: an evolutionary medicine perspective.BMC medicine · 2015Review
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Authors and funding
12 authors at 8 institutions in 7 countries.
Funding
Abstract
The study of the genetic and selective landscape of immunity genes across primates can provide insight into the existing differences in susceptibility to infection observed between human and non-human primates. Here, we explored how selection has driven the evolution of a key family of innate immunity receptors, the Toll-like receptors (TLRs), in African great ape species. We sequenced the 10 TLRs in various populations of chimpanzees and gorillas, and analysed these data jointly with a human data set. We found that purifying selection has been more pervasive in great apes than in humans. Furthermore, in chimpanzees and gorillas, purifying selection has targeted TLRs irrespectively of whether they are endosomal or cell surface, in contrast to humans where strong selective constraints are restricted to endosomal TLRs. These observations suggest important differences in the relative importance of TLR-mediated pathogen sensing, such as that of recognition of flagellated bacteria by TLR5, between humans and great apes. Lastly, we used a population genetics-phylogenetics method that jointly analyses polymorphism and divergence data to detect fine-scale variation in selection pressures at specific codons within TLR genes. We identified different codons at different TLRs as being under positive selection in each species, highlighting that functional variation at these genes has conferred a selective advantage in immunity to infection to specific primate species. Overall, this study showed that the degree of selection driving the evolution of TLRs has largely differed between human and non-human primates, increasing our knowledge on their respective biological contribution to host defence in the natural setting.
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