ArticleJournal of the American College of Cardiology2013
Body fat distribution, incident cardiovascular disease, cancer, and all-cause mortality.
Article in Journal of the American College of Cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03038620 (Impact of Liraglutide 3.0 on Body Fat Distribution, Visceral Adiposity, and Cardiometabolic Risk Markers In Overweight and Obese Adults at High Risk for Cardiovascular Disease), which is not on this map. Cited by 342 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Liraglutide 3.0 on Body Fat Distribution, Visceral Adiposity, and Cardiometabolic Risk Markers In Overweight and Obese Adults at High Risk for Cardiovascular Disease
Who cites it
342 citing papers in PubMed, 10 syntheses or guidelines pooled it, 689 citations in OpenAlex.
- Validity of non-traditional measures of obesity compared to total body fat across the life course: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Pooled it
- The predictive value of a body shape index as a novel obesity metric for cancer risk: a systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Linking abnormal fat distribution with HFpEF and diastolic dysfunction: a systematic review, meta-analysis, and meta-regression of observational studies.Lipids in health and disease · 2024Pooled it
- Assessment of correlation between conventional anthropometric and imaging-derived measures of body fat composition: a systematic literature review and meta-analysis of observational studies.BMC medical imaging · 2023Pooled it
- Digital Anthropometry: A Systematic Review on Precision, Reliability and Accuracy of Most Popular Existing Technologies.Nutrients · 2023Pooled it
- Body fat and risk of all-cause mortality: a systematic review and dose-response meta-analysis of prospective cohort studies.International journal of obesity (2005) · 2022Pooled it
- Abdominal Visceral Adipose Tissue and All-Cause Mortality: A Systematic Review.Frontiers in endocrinology · 2022Pooled it
- Impact of CPAP treatment for obstructive sleep apnea on visceral adipose tissue: a meta-analysis of randomized controlled trials.Sleep & breathing = Schlaf & Atmung · 2021Pooled it
- The range of non-traditional anthropometric parameters to define obesity and obesity-related disease in children: a systematic review.European journal of clinical nutrition · 2021Pooled it
- The performance of anthropometric tools to determine obesity: a systematic review and meta-analysis.Scientific reports · 2020Pooled it
- Mediterranean diet vs. the Australian guide to healthy eating (AGHE) on body composition and glucose metabolism: A randomized controlled trial.Diabetes, obesity & metabolism · 2025Trial
- Sex moderates diet quality differences in integrated collaborative care for comorbid obesity and depression: Post-hoc analysis of the RAINBOW RCT.The journal of nutrition, health & aging · 2025Trial
- An Energy-Reduced Mediterranean Diet, Physical Activity, and Body Composition: An Interim Subgroup Analysis of the PREDIMED-Plus Randomized Clinical Trial.JAMA network open · 2023Trial
- Longitudinal association of dietary carbohydrate quality with visceral fat deposition and other adiposity indicators.Clinical nutrition (Edinburgh, Scotland) · 2022Trial
- Effects of Experimental Sleep Restriction on Energy Intake, Energy Expenditure, and Visceral Obesity.Journal of the American College of Cardiology · 2022Trial
- Effectiveness of Minimal Contact Interventions: An RCT.American journal of preventive medicine · 2021Trial
- Effects of caloric restriction on human physiological, psychological, and behavioral outcomes: highlights from CALERIE phase 2.Nutrition reviews · 2021Trial
- Linking visceral fat accumulation to gut microbiota: key bacterial taxa and their roles in the glycogen synthesis pathway.Experimental & molecular medicine · 2026Article
- Obesity at antiretroviral therapy initiation and long-term risk of cardiovascular disease, cancer, or death in people with HIV in Italy: a prospective cohort study.EClinicalMedicine · 2026Article
- Associations of cumulative exposure and dynamic trajectories of the cholesterol-HDL-glucose index and its obesity-related derivatives with cardiovascular disease: a nationwide prospective cohort study.Cardiovascular diabetology · 2026Article
282 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesThe aim of this study was to determine whether ectopic fat depots are prospectively associated with cardiovascular disease, cancer, and all-cause mortality.
backgroundThe morbidity associated with excess body weight varies among individuals of similar body mass index. Ectopic fat depots may underlie this risk differential. However, prospective studies of directly measured fat are limited.
methodsParticipants from the Framingham Heart Study (n = 3,086; 49% women; mean age of 50.2 years) underwent assessment of fat depots (visceral adipose tissue, pericardial adipose tissue, and periaortic adipose tissue) using multidetector computed tomography and were followed up longitudinally for a median of 5.0 years. Cox proportional hazards regression models were used to examine the association of each fat depot (per 1 SD increment) with the risk of incident cardiovascular disease, cancer, and all-cause mortality after adjustment for standard risk factors, including body mass index.
resultsOverall, there were 90 cardiovascular events, 141 cancer events, and 71 deaths. After multivariable adjustment, visceral adipose tissue was associated with cardiovascular disease (hazard ratio: 1.44; 95% confidence interval: 1.08 to 1.92; p = 0.01) and cancer (hazard ratio: 1.43; 95% confidence interval: 1.12 to 1.84; p = 0.005). Addition of visceral adipose tissue to a multivariable model that included body mass index modestly improved cardiovascular risk prediction (net reclassification improvement of 16.3%). None of the fat depots were associated with all-cause mortality.
conclusionsVisceral adiposity is associated with incident cardiovascular disease and cancer after adjustment for clinical risk factors and generalized adiposity. These findings support the growing appreciation of a pathogenic role of ectopic fat.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.