ArticleJournal of the American College of Cardiology2013
Derivation and validation of diagnostic thresholds for central blood pressure measurements based on long-term cardiovascular risks.
Article in Journal of the American College of Cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02704468 (FGF21 Can Help Predicting Arterial Stiffness Measured by Cardio-ankle Vascular Index in Renal Transplant Patients), which is not on this map. Cited by 63 papers, 4 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
FGF21 Can Help Predicting Arterial Stiffness Measured by Cardio-ankle Vascular Index in Renal Transplant Patients
Who cites it
63 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Association of cardiovascular events with central systolic blood pressure: A systemic review and meta-analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2024Pooled it
- Risk Stratification by Cross-Classification of Central and Brachial Systolic Blood Pressure.Hypertension (Dallas, Tex. : 1979) · 2022Pooled it
- The International Database of Central Arterial Properties for Risk Stratification: Research Objectives and Baseline Characteristics of Participants.American journal of hypertension · 2022Pooled it
- Effects of Resistance Training on Arterial Stiffness in Persons at Risk for Cardiovascular Disease: A Meta-analysis.Sports medicine (Auckland, N.Z.) · 2018Pooled it
- Central blood pressure for the management of hypertension: Is it a practical clinical tool in current practice?Journal of clinical hypertension (Greenwich, Conn.) · 2020Trial
- Association of Morning Hypertension Subtype With Vascular Target Organ Damage and Central Hemodynamics.Journal of the American Heart Association · 2017Trial
- The simplified method for quantifying metabolic syndrome (siMS) score reflects an increased cardiometabolic burden: adiposity, hemodynamics, and HRV findings in young adults.Journal of diabetes and metabolic disorders · 2026Article
- Carotid pulsatile energy fraction surpasses traditional hemodynamic markers in explaining cognitive impairment among hemodialysis patients.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Central Blood Pressure and Augmentation Index in Older Adults With Intellectual Disabilities.Journal of intellectual disability research : JIDR · 2025Article
- Influence of Age and Central Hypertension on the Form Factor Needed to Estimate Mean Aortic Pressure, and Its Implications for Pulse Pressure Amplification: A Secondary Data Analysis.Journal of the American Heart Association · 2025Article
- Central Hemodynamics in African American Women: Examining the Role of Superwoman Schema Endorsement.Journal of the American Heart Association · 2024Article
- Genetic variation in CCDC93 is associated with elevated central systolic blood pressure, impaired arterial relaxation, and mitochondrial dysfunction.PLoS genetics · 2024Article
- 2024 Guidelines of the Taiwan Society of Cardiology on the Primary Prevention of Atherosclerotic Cardiovascular Disease --- Part I.Acta Cardiologica Sinica · 2024Article
- Association of central blood pressure with an exaggerated blood pressure response to exercise among elite athletes.European journal of applied physiology · 2024Article
- Arterial Health After Preeclampsia: Role of Chronic Hypertension in the Early Vascular Aging (EVA) Study.American journal of hypertension · 2024Article
- Hypertension in China: epidemiology and treatment initiatives.Nature reviews. Cardiology · 2023Review
- Brachial and central hypertension in relation to coronary stenosis in patients with coronary angiography.Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
- Prognostic value of central blood pressure on the outcomes of embolic stroke of undetermined source.Scientific reports · 2023Article
- 130/80 mmHg as a unifying hypertension threshold for office brachial, office central, and ambulatory daytime brachial blood pressure.Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
- CENtral blood pressure Targeting: a pragmatic RAndomized triaL in advanced Chronic Kidney Disease (CENTRAL-CKD): A Clinical Research Protocol.Canadian journal of kidney health and disease · 2023Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
Abstract
objectivesThis study sought to derive and validate outcome-driven thresholds of central blood pressure (CBP) for diagnosing hypertension.
backgroundCurrent guidelines for managing patients with hypertension mainly rely on blood pressure (BP) measured at brachial arteries (cuff BP). However, BP measured at the central aorta (central BP [CBP]) may be a better prognostic factor for predicting future cardiovascular events than cuff BP.
methodsIn a derivation cohort (1,272 individuals and a median follow-up of 15 years), we determined diagnostic thresholds for CBP by using current guideline-endorsed cutoffs for cuff BP with a bootstrapping (resampling by drawing randomly with replacement) and an approximation method. To evaluate the discriminatory power in predicting cardiovascular outcomes, the derived thresholds were tested in a validation cohort (2,501 individuals with median follow-up of 10 years).
resultsThe 2 analyses yielded similar diagnostic thresholds for CBP. After rounding, systolic/diastolic threshold was 110/80 mm Hg for optimal BP and 130/90 mm Hg for hypertension. Compared with optimal BP, the risk of cardiovascular mortality increased significantly in subjects with hypertension (hazard ratio: 3.08, 95% confidence interval: 1.05 to 9.05). Of the multivariate Cox proportional hazards model, incorporation of a dichotomous variable by defining hypertension as CBP ≥ 130/90 mm Hg was associated with the largest contribution to the predictive power.
conclusionsCBP of 130/90 mm Hg was determined to be the cutoff limit for normality and was characterized by a greater discriminatory power for long-term events in our validation cohort. This report represents an important step toward the application of the CBP concept in clinical practice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.