ArticleDevelopmental biology2013
The neuronal transcription factor erect wing regulates specification and maintenance of Drosophila R8 photoreceptor subtypes.
Article in Developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Cell type-specific functions of the PBAF chromatin-remodeling complex in neuronal diversification.Nature communications · 2025Article
- Trithorax regulates long-term memory in Drosophila through epigenetic maintenance of mushroom body metabolic state and translation capacity.PLoS biology · 2025Article
- Genome-Wide Association Study and transcriptome analysis reveals a complex gene network that regulates opsin gene expression and cell fate determination inbioRxiv : the preprint server for biology · 2024Article
- Neurexin-1-dependent circuit activity is required for the maintenance of photoreceptor subtype identity in Drosophila.Molecular brain · 2024Article
- A single cell genomics atlas of the Drosophila larval eye reveals distinct photoreceptor developmental timelines.Nature communications · 2023Article
- Maintenance of neuronal fate and transcriptional identity.Biology open · 2023Review
- Psi promotes Drosophila wing growth via direct transcriptional activation of cell cycle targets and repression of growth inhibitors.Development (Cambridge, England) · 2023Article
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- NRF1 association with AUTS2-Polycomb mediates specific gene activation in the brain.Molecular cell · 2021Article
- Application of Fluorescent Proteins for Functional Dissection of theInternational journal of molecular sciences · 2021Review
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- Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis.Molecular neurodegeneration · 2018Article
- highroad Is a Carboxypetidase Induced by Retinoids to Clear Mutant Rhodopsin-1 in Drosophila Retinitis Pigmentosa Models.Cell reports · 2018Article
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- Computational genome-wide survey of odorant receptors from two solitary bees Dufourea novaeangliae (Hymenoptera: Halictidae) and Habropoda laboriosa (Hymenoptera: Apidae).Scientific reports · 2017Article
- Parallel Activin and BMP signaling coordinates R7/R8 photoreceptor subtype pairing in the stochasticeLife · 2017Article
- Regulatory logic driving stable levels ofDevelopment (Cambridge, England) · 2017Article
- The insulator protein BEAF-32 is required for Hippo pathway activity in the terminal differentiation of neuronal subtypes.Development (Cambridge, England) · 2016Article
- Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Signaling pathways are often re-used during development in surprisingly different ways. The Hippo tumor suppressor pathway is best understood for its role in the control of growth. The pathway is also used in a very different context, in the Drosophila eye for the robust specification of R8 photoreceptor neuron subtypes, which complete their terminal differentiation by expressing light-sensing Rhodopsin (Rh) proteins. A double negative feedback loop between the Warts kinase of the Hippo pathway and the PH-domain growth regulator Melted regulates the choice between 'pale' R8 (pR8) fate defined by Rh5 expression and 'yellow' R8 (yR8) fate characterized by Rh6 expression. Here, we show that the gene encoding the homolog of human Nuclear respiratory factor 1, erect wing (ewg), is autonomously required to inhibit warts expression and to promote melted expression to specify pR8 subtype fate and induce Rh5. ewg mutants express Rh6 in most R8s due to ectopic warts expression. Further, ewg is continuously required to maintain repression of Rh6 in pR8s in aging flies. Our work shows that Ewg is a critical factor for the stable down-regulation of Hippo pathway activity to determine neuronal subtype fates. Neural-enriched factors, such as Ewg, may generally contribute to the contextual re-use of signaling pathways in post-mitotic neurons.
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