ArticleFish & shellfish immunology2013
Evidence for Paralichthys olivaceus IFITM1 antiviral effect by impeding viral entry into target cells.
Article in Fish & shellfish immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Intrinsic antiviral immunity of barrier cells revealed by an iPSC-derived blood-brain barrier cellular model.Cell reports · 2022Article
- Positive Regulation of the Antiviral Activity of Interferon-Induced Transmembrane Protein 3 by S-Palmitoylation.Frontiers in immunology · 2022Review
- Swine Interferon-Inducible Transmembrane Proteins Potently Inhibit African Swine Fever Virus Replication.Frontiers in immunology · 2022Article
- Grouper Interferon-Induced Transmembrane Protein 1 Inhibits Iridovirus and Nodavirus Replication by Regulating Virus Entry and Host Lipid Metabolism.Frontiers in immunology · 2021Article
- Host antiviral protein IFITM2 restricts pseudorabies virus replication.Virus research · 2020Article
- Current Progress on Host Antiviral Factor IFITMs.Frontiers in immunology · 2020Review
- Functional Involvement of Interferon-Inducible Transmembrane Proteins in Antiviral Immunity.Frontiers in microbiology · 2019Review
- Effects of different cytokines on immune responses of rainbow trout in a virus DNA vaccination model.Oncotarget · 2017Article
- Natural mutations in IFITM3 modulate post-translational regulation and toggle antiviral specificity.EMBO reports · 2016Article
- Article
- IFITMs from Mycobacteria Confer Resistance to Influenza Virus When Expressed in Human Cells.Viruses · 2015Article
- P247 and p523: two in vivo-expressed megalocytivirus proteins that induce protective immunity and are essential to viral infection.PloS one · 2015Article
- Regulation of the trafficking and antiviral activity of IFITM3 by post-translational modifications.Future microbiology · 2014Review
- IFITMs restrict the replication of multiple pathogenic viruses.Journal of molecular biology · 2013Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interferon-inducible transmembrane (IFITM) protein family is novel viral restriction factors with representative transmembrane structure. These proteins also exist in fish, however, their roles in the innate immune response remain unknown. Here, we report a characterization of teleost IFITM1 from flounder Paralichthys olivaceus (PoIFITM1), which exhibits conserved structure characteristic of the IFITM family but comprises a relatively longer N-terminal region. The expression and promoter activity of PoIFITM1 are markedly induced by aquatic animal viruses: Rana grylio virus (RGV) and Scophthalmus maximus rhabdovirus (SMRV). Overexpression and siRNA-mediated knockdown demonstrate that PoIFITM1 exhibits strong antiviral effects against both DNA virus (RGV) and RNA virus (SMRV), expanding the spectrum of viruses inhibited by IFITM proteins. Further analysis shows that PoIFITM1 suppresses viral entry into host cells, confirming that the IFITM-mediated restriction is conserved from lower vertebrates to mammals. Deletion mutagenesis reveals that PoIFITM1 exerts antiviral activity by targeting to Golgi complex and the N-terminal region is required for its subcellular localization, which is not observed in other known IFITM family members. Our current data provide the first evidence that IFITM1 functions as a key effector of the innate immune to restrict virus replication in lower vertebrates, through the action of impeding viral entry.
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