Trial reportAutonomic neuroscience : basic & clinical2013
Laser Doppler imaging in the detection of peripheral neuropathy.
Trial report in Autonomic neuroscience : basic & clinical, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Corneal Confocal Microscopy as a Non-Invasive Marker of Small Fiber Neuropathy and Systemic Complications in Type 2 Diabetes: A Cross-Sectional Study.Biomolecules · 2026Observational
- Laser Doppler mapping of lower limb skin perfusion before and 5 h after exercise in warm conditions.Frontiers in physiology · 2026Article
- Screening and monitoring of diabetic polyneuropathy in clinical practice: present and future with connected devices.Frontiers in neurology · 2025Article
- Autonomic nervous system disorders in multiple sclerosis.Journal of neurology · 2023Review
- Functional and structural markers of peripheral microvascular autonomic neuropathy.Muscle & nerve · 2023Article
- Contactless photoplethysmography for assessment of small fiber neuropathy.Frontiers in physiology · 2023Article
- Remote Photoplethysmography for Evaluation of Cutaneous Sensory Nerve Fiber Function.Sensors (Basel, Switzerland) · 2021Article
- A Systematic Review of the Diagnostic Methods of Small Fiber Neuropathies in Rehabilitation.Diagnostics (Basel, Switzerland) · 2020Review
- Assessment of cutaneous axon-reflex responses to evaluate functional integrity of autonomic small nerve fibers.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Review
- Longitudinal Study of Functional Reinnervation of the Denervated Skin by Collateral Sprouting of Peptidergic Nociceptive Nerves Utilizing Laser Doppler Imaging.Frontiers in physiology · 2020Article
- Architecture of the Cutaneous Autonomic Nervous System.Frontiers in neurology · 2019Review
- Should Skin Biopsies Be Performed in Patients Suspected of Having Parkinson's Disease?Parkinson's disease · 2017Review
- Laser Doppler Assessment of Vasomotor Axon Reflex Responsiveness to Evaluate Neurovascular Function.Frontiers in neurology · 2017Review
- Alpha-synuclein in cutaneous small nerve fibers.Neuropsychiatric disease and treatment · 2016Article
- Autonomic Dysregulation in Multiple Sclerosis.International journal of molecular sciences · 2015Review
- Heart rate variability biofeedback in patients with alcohol dependence: a randomized controlled study.Neuropsychiatric disease and treatment · 2015Article
- [Axon-reflex based nerve fiber function assessment in the detection of autonomic neuropathy].Der Nervenarzt · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Small fiber neuropathy is common in a number of systemic diseases and is often challenging to diagnose. Laser Doppler imaging (LDI) is a test of small fiber neurovascular function that can quantify the integrity of the vasomotor C-fiber mediated axon-reflex, but no standardized method of analysis exists. We developed a novel LDI analysis technique and tested it in a human model of small fiber neuropathy. Eighteen healthy subjects (age 24 ± 3 years) underwent LDI testing to assess the axon-mediated flare area in response to 10% acetylcholine iontophoresis. LDI measurements were taken before and longitudinally after a 48-hour application of 0.1% capsaicin (to cause a transient small fiber neuropathy) on the skin of the thigh; placebo cream was placed on the contralateral thigh as a control. We compared our new LDI image analysis technique to two previously published methods. The new LDI analysis technique was the only method to show a consistent difference in axon-reflex area between capsaicin treated and placebo treated skin on all testing days (p<0.05) with maximum attenuation of the flare area immediately post-application (438 ± 298 mm(2) vs. 824 ± 375 mm(2), p<0.05). In conclusion, this study demonstrates that our novel flare area method for LDI analysis can detect neurovascular dysfunction in a model of small fiber neuropathy, is an improvement over existing methods, and may supplement clinical assessment of small fiber neuropathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.