ArticleNeurobiology of aging2013
Estimated maximal and current brain volume predict cognitive ability in old age.
Article in Neurobiology of aging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Is intracranial volume a suitable proxy for brain reserve?Alzheimer's research & therapy · 2018Pooled it
- Exploring the link between body physiology and cognition: the role of the brain and aging.npj aging · 2026Article
- NeuroFM: Toward Precision Neuroimaging with Foundation Models for Individualized Brain Health Estimation.medRxiv : the preprint server for health sciences · 2026Article
- White Matter Bundle Reconstruction From Single-Shell Diffusion Magnetic Resonance Imaging: Test-Retest Reliability and Predictive Capability Across Orientation Distribution Function Reconstruction Methods.Human brain mapping · 2025Article
- Plasma and CSF Amyloid-β42 Predict Plasma Sortilin, Which Influences Cognitive Impairment via Mediation of Whole-Brain Volume: A 12-Month Longitudinal Study Across the Alzheimer's Disease Spectrum.Journal of molecular neuroscience : MN · 2025Article
- Aortic Stiffness and Alzheimer's Disease: The Medin Connection.Biomolecules · 2025Review
- Age-Associated Cortical Thinning in Speech Motor Regions Precedes Hippocampal Decline: Implications for Alzheimer's Disease.Human brain mapping · 2025Article
- Association of multimorbidity and disease clusters with neuroimaging and cognitive outcomes in UK Biobank.The journal of prevention of Alzheimer's disease · 2025Article
- Measurement characteristics and genome-wide correlates of lifetime brain atrophy estimated from a single MRI.Nature communications · 2025Article
- A lifespan-generalizable skull-stripping model for magnetic resonance images that leverages prior knowledge from brain atlases.Nature biomedical engineering · 2025Article
- Quantifying motor-cognitive reserve using a novel multi-modal stress test.Brain communications · 2025Article
- Inflammatory protein associations with brain MRI measures: Framingham Offspring Cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- The Influence of Structural Brain Changes on Cognition in the Context of Healthy Aging: Exploring Mediation Effects Through gBAT-The Graphical Brain Association Tool.Human brain mapping · 2024Article
- A blood biomarker of the pace of aging is associated with brain structure: replication across three cohorts.Neurobiology of aging · 2024Article
- Brain health measurement: a scoping review.BMJ open · 2024Article
- Association of cancer history with structural brain aging markers of Alzheimer's disease and related dementias risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Brain volume is a better biomarker of outcomes in ischemic stroke compared to brain atrophy.Frontiers in stroke · 2024Article
- A blood biomarker of accelerated aging in the body associates with worse structural integrity in the brain: replication across three cohorts.medRxiv : the preprint server for health sciences · 2023Article
- Causal effects of serum testosterone levels on brain volume: a sex-stratified Mendelian randomization study.Journal of endocrinological investigation · 2023Article
- Investigation of genetic variants and causal biomarkers associated with brain aging.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Brain tissue deterioration is a significant contributor to lower cognitive ability in later life; however, few studies have appropriate data to establish how much influence prior brain volume and prior cognitive performance have on this association. We investigated the associations between structural brain imaging biomarkers, including an estimate of maximal brain volume, and detailed measures of cognitive ability at age 73 years in a large (N = 620), generally healthy, community-dwelling population. Cognitive ability data were available from age 11 years. We found positive associations (r) between general cognitive ability and estimated brain volume in youth (male, 0.28; females, 0.12), and in measured brain volume in later life (males, 0.27; females, 0.26). Our findings show that cognitive ability in youth is a strong predictor of estimated prior and measured current brain volume in old age but that these effects were the same for both white and gray matter. As 1 of the largest studies of associations between brain volume and cognitive ability with normal aging, this work contributes to the wider understanding of how some early-life factors influence cognitive aging.
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Registered trials
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