ArticlePsychoneuroendocrinology2013
Self-reported sleep disturbance is associated with lower CD4 count and 24-h urinary dopamine levels in ethnic minority women living with HIV.
Article in Psychoneuroendocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 4 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Poor sleep quality and its associated factors among HIV/ADIS patients living in sub-Saharan African countries: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- The prevalence and moderating factors of sleep disturbances in people living with HIV: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Non-pharmacological interventions for improving sleep in people living with HIV: a systematic narrative review.Frontiers in neurology · 2023Pooled it
- Ambulatory Blood Pressure Monitoring in Individuals with HIV: A Systematic Review and Meta-Analysis.PloS one · 2016Pooled it
- Trial
- Sleep health epidemiology in adults with and without HIV in Mwanza, Tanzania: Baseline results from an ongoing cohort study.Sleep epidemiology · 2026Article
- Sleep actigraphy results and HIV health outcomes in an urban HIV clinic sample.Psychology, health & medicine · 2025Article
- Assessing sleep using the Pittsburgh Sleep Quality Index (PSQI) among comorbid HIV and psychiatric outpatients.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2025Article
- Psychological Mechanisms of Internalized HIV Stigma Affect Sleep Impairment among People Living with HIV in China: A follow-up Study.AIDS and behavior · 2024Article
- Shorter total sleep time is associated with lower CD4+/CD8+ T cell ratios in virally suppressed men with HIV.Sleep advances : a journal of the Sleep Research Society · 2024Article
- Sleep deficiency among people living with human immunodeficiency virus: A growing challenge.HIV medicine · 2024Review
- Poor subjective sleep reported by people living with HIV is associated with impaired working memory.NeuroImmune pharmacology and therapeutics · 2023Article
- Article
- Current Challenges and Solutions for Clinical Management and Care of People with HIV: Findings from the 12th Annual International HIV and Aging Workshop.AIDS research and human retroviruses · 2023Article
- Article
- Sleep Disturbances and Chronic Pain in People with HIV: Implications for HIV-Associated Neurocognitive Disorders.Current sleep medicine reports · 2022Article
- Observational
- COVID-19 and preventive strategy.American journal of cardiovascular disease · 2022Review
- Relationships Among Trajectories of Sleep Disturbance, Depression, and Antiretroviral Therapy in Persons Newly Diagnosed with HIV: A One-and-a-Half-Year Observational Longitudinal Study.Nature and science of sleep · 2022Article
- Sleep and immune function among people living with human immunodeficiency virus (HIV).AIDS care · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSleep disturbance is associated with dopamine dysregulation, which can negatively impact immune status. Individuals living with HIV experience more sleep difficulties, and poor sleep may compound immune decrements associated with HIV infection. Little research has examined associations between sleep, dopamine, and immune status (CD4 count) in individuals with HIV. As ethnic minority women living with HIV (WLWH) are at heightened risk for HIV disease progression, we related sleep reports to both CD4 count and dopamine levels in a cohort of ethnic minority WLWH.
methodsParticipants were 139 low-income WLWH (ages 20-62; 78.3% African-American or Caribbean) who reported both overall sleep quality and sleep disturbance on the Pittsburgh sleep quality index (PSQI). CD4 count and HIV viral load were measured via morning peripheral venous blood samples, and concentrations of dopamine were measured via 24-h urine collection. Covariates included HIV viral load, length of time since HIV diagnosis, HAART adherence, perceived stress and depression.
resultsAfter controlling for all covariates, greater sleep disturbance was associated with significantly lower CD4 count (β=-.20, p=.03) and lower levels of dopamine (β=-.25, p=.04). Poorer overall sleep quality was marginally associated with lower CD4 count (β=-.16, p=.08), and was not associated with dopamine.
conclusionOur analyses suggest that sleep disturbance is independently related with immune status and dopamine levels in WLWH. Lower levels of dopamine may indicate neuroendocrine dysregulation and may impact immune and health status. Results highlight sleep disturbance rather than overall sleep quality as potentially salient to neuroendocrine and immune status in ethnic minority WLWH.
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