Evidence map›Paper›PMID 23850195›Full record

Trial reportJournal of the American Society of Hypertension : JASH

Reproducibility of blood pressure dipping: relation to day-to-day variability in sleep quality.

Alan L Hinderliter, Faye S Routledge, James A Blumenthal, Gary Koch, Michael A Hussey, William K Wohlgemuth, Andrew Sherwood

Abstract readClinical TrialValidation Study
In one paragraph

Trial report in Journal of the American Society of Hypertension : JASH. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Trial
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  17. Review
  18. Article
  19. Diurnal blood pressure changes.Hypertension research : official journal of the Japanese Society of Hypertension · 2018
    Review
  20. Waking up to the importance of sleeping well for cardiovascular health.Journal of clinical hypertension (Greenwich, Conn.) · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alan L HinderliterUniversity of North Carolina at Chapel Hill, Chapel Hill, NC. Electronic address: hinderli@med.unc.edu.
Faye S RoutledgeDuke University Medical Center, Durham, NC; Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA.
James A BlumenthalDuke University Medical Center, Durham, NC.
Gary KochUniversity of North Carolina at Chapel Hill, Chapel Hill, NC.
Michael A HusseyUniversity of North Carolina at Chapel Hill, Chapel Hill, NC.
William K WohlgemuthPsychology Service, Miami VA Healthcare System, Miami, FL.
Andrew SherwoodDuke University Medical Center, Durham, NC.

Funding

XOMAZYME-CD5 PLUS THERAPY IN RHEUMATOID ARTHRITISM01RR000030 · NCRR · DUKE UNIVERSITY · PI WILLIAMS, R SANDERS · 1985 to 2006
$20.0M
Biobehavioral Mechanisms of Blood Pressure DippingR01HL072390 · NHLBI · DUKE UNIVERSITY · PI SHERWOOD, ANDREW · 2003 to 2006
$2.2M
NCRR NIH HHS M01 RR000030NCRR NIH HHS M01-RR-30NHLBI NIH HHS HL072390NHLBI NIH HHS R01 HL072390
6 · The paper itself

Abstract

Previous studies of the reproducibility of blood pressure (BP) dipping have yielded inconsistent results. Few have examined factors that may influence day-to-day differences in dipping. Ambulatory BP monitoring was performed on three occasions, approximately 1 week apart, in 115 untreated adult subjects with elevated clinic BPs. The mean ± standard deviation BP dip was 18 ± 7/15 ± 5 mm Hg (sleep/awake BP ratio = 0.87 ± 0.05/0.82 ± 0.06), with a median (interquartile range) day-to-day variation of 5.2 (3.1-8.1)/4.3 (2.8-5.6) mm Hg. There was no decrease in variability with successive measurements. The reproducibility coefficient (5.6 [95% confidence interval, 5.1-6.1] mm Hg) was greater and the intraclass correlation coefficient (0.53 [95% confidence interval, 0.42-0.63]) was smaller for the systolic dip than for 24-hour or awake systolic BPs, suggesting greater day-to-day variability in dipping. Variability in systolic dipping was greater in subjects with higher awake BP, but was not related to age, gender, race, or body mass index. Within individuals, day-to-day variations in dipping were related to variations in the fragmentation index (P < .001), a measure of sleep quality. Although mean 24-hour and awake BPs were relatively stable over repeated monitoring days, our study confirms substantial variability in BP dipping. Day-to-day differences in dipping are related to sleep quality.

Indexed as

ActigraphyAdultBlood PressureBlood Pressure Monitoring, AmbulatoryCircadian RhythmFemaleHealthy VolunteersHumansHypertensionMaleMiddle AgedReproducibility of ResultsSleepSleep DeprivationactigraphyAmbulatory blood pressure monitoringfragmentation index

Identifiers

PMID23850195
PMCPMC3865136

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.