Evidence map›Paper›PMID 23850004›Full record

ReviewCytokine2013

Adiponectin in inflammatory and immune-mediated diseases.

Giamila Fantuzzi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cytokine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 2 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 2 syntheses or guidelines pooled it, 171 citations in OpenAlex.

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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Giamila FantuzziDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, 1919 W Taylor Street MC517, Chicago, IL 60613, United States. Electronic address: giamila@uic.edu.
University of Illinois Chicago · US

Funding

Acute pancreatitis and obesityR01DK083328 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI FANTUZZI, GIAMILA · 2010 to 2013
$1.4M
NIDDK NIH HHS DK083328NIDDK NIH HHS R01 DK083328
6 · The paper itself

Abstract

Circulating levels of adiponectin (APN) are reduced in obesity and associated comorbidities, with inflammation playing an important role in downregulating APN production. In contrast to obesity and metabolic disease, elevated systemic and local levels of APN are present in patients with inflammatory and immune-mediated diseases, including autoimmune and pulmonary conditions, heart and kidney failure, viral hepatitis, organ transplantation and perhaps critical illness. A positive association between inflammation and APN is usually reported in inflammatory/immune pathologies, in contrast with the negative correlation typical of metabolic disease. This review discusses the role of APN in modulation of inflammation and immunity and the potential mechanisms leading to increased levels of APN in inflammatory/immune diseases, including modification of adipose tissue physiology; relative contribution of different tissues and adipose depots; hormonal, pharmacological, nutritional and life style factors; the potential contribution of the microbiota as well as the role of altered APN clearance and release from T-cadherin-associated tissue reservoirs. Potential reasons for some of the apparently contradictory findings on the role of APN as a modulator of immunity and inflammation are also discussed, including a comparison of types of recombinant APN used for in vitro studies and strain-dependent differences in the phenotype of APN KO mice.

Indexed as

AdiponectinAdipose TissueAnimalsDisease Models, AnimalHeart DiseasesHumansImmune System DiseasesInflammationLung DiseasesMiceMice, KnockoutObesityOrgan TransplantationRenal InsufficiencyAdiponectinAdipokinesadiponectinAdipose tissueAPNBMIbody mass indexcardiovascular diseasechronic obstructive pulmonary diseaseCOPDCVDDiseasegraft-versus-host diseaseGVHDImmunityInflammationlipopolysaccharideLPSmolecular weightMWperoxisome proliferator-activated receptorPPARTLRtoll-like receptor

Identifiers

PMID23850004
PMCPMC3770746
OpenAlexW2044076507

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.